| Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury. | |
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MedLine Citation:
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PMID: 22267391 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Physical activity modulates inflammation and immune response in both normal and pathologic conditions. We investigated whether regular and moderate exercise before the induction of experimental sepsis reduces the risk of lung and distal organ injury and survival. One hundred and twenty-four BALB/c mice were randomly assigned to 2 groups: sedentary (S) and trained (T). Animals in T group ran on a motorized treadmill, at moderate intensity, 5% grade, 30 min/day, 3 times a week for 8 weeks. Cardiac adaptation to exercise was evaluated using echocardiography. Systolic volume and left ventricular mass were increased in T compared to S group. Both T and S groups were further randomized either to sepsis-induced by cecal ligation and puncture surgery (CLP) or sham operation (control). After 24 hours, lung mechanics and histology, the degree of cell apoptosis in lung, heart, kidney, liver, and small intestine villi, and interleukin (IL)-6, KC (IL-8 murine functional homolog), IL-1β, IL-10, and number of cells in bronchoalveolar lavage (BALF) and peritoneal lavage (PLF) fluids as well as plasma were measured. In CLP, T compared to S groups, showed: 1) improvement in survival; 2) reduced lung static elastance, alveolar collapse, collagen and elastic fiber content, number of neutrophils in BALF, PLF, and plasma, as well as lung and distal organ cell apoptosis; and 3) increased IL-10 in BALF and plasma, with reduced IL-6, KC, and IL-1β in PLF. In conclusion, regular and moderate exercise before the induction of sepsis reduced the risk of lung and distal organ damage, thus increasing survival. |
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Authors:
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Carla Cristina de Araújo; Johnatas Dutra Silva; Cynthia Dos Santos Samary; Isabela Henriques Guimarães; Patricia da Silva Marques; Gisele Pena Oliveira; Luana Gouveia Rio Rocha do Carmo; Regina Coeli Goldenberg; Ilka Bakker-Abreu; Bruno Lourenço Diaz; Nazareth de Novaes Rocha; Vera Luiza Capelozzi; Paolo Pelosi; Patricia Rieken Macedo Rocco |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Federal University of Rio de Janeiro. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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