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Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism.
MedLine Citation:
PMID:  21893033     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fatty liver is known as the initial stage in nonalcoholic fatty liver disease. Epidemiological studies have shown that regular exercise prevents accumulation of hepatic lipids, although the underlying mechanism is unclear. The purpose of this study was to investigate the effect of exercise on fatty liver associated with hepatic lipid metabolism. KK/Ta mice (6weeks old) were divided into sedentary and exercise groups and compared with sedentary Balb/c mice. All the mice were fed a high-sucrose diet for 12weeks. The KK/Ta mice in the exercise group performed a treadmill running exercise at 20m/min for 30min (3 times per week). Twelve weeks of regular exercise suppressed the accumulation of lipid in the liver, along with reduction in the level of lipid in the plasma. The levels of carnitine palmitoyl transferase II, acyl-coenzyme A dehydrogenase, and trifunctional enzyme, which are rate-limiting enzymes in fatty acid oxidation in the liver, were elevated by exercise. In addition, the expression of fatty acid synthase, a key lipogenetic enzyme, was reduced by exercise. Furthermore, regular exercise decreased the expression of heat shock protein 47, a marker of hepatic fibrosis, in the liver. Our results suggest that regular exercise prevents fatty liver via improvement of hepatic lipid metabolism.
Authors:
Wataru Aoi; Yuji Naito; Liu Po Hung; Kazuhiko Uchiyama; Satomi Akagiri; Katsura Mizushima; Toshikazu Yoshikawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-27
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  -     ISSN:  1090-2104     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan.
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