Document Detail

Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury.
MedLine Citation:
PMID:  9096376     Owner:  NLM     Status:  MEDLINE    
Epidemiologic studies indicate that long-term alcohol consumption decreases the incidence of coronary disease and may improve outcome after myocardial infarction. Attenuation of ischemia-reperfusion injury after myocardial infarction improves survival. This study investigates the possibility that alcohol consumption can improve survival after myocardial infarction by reducing ischemia-reperfusion injury. Hearts were isolated from guinea pigs after drinking ethanol for 3-12 weeks and subjected to global ischemia and reperfusion. Hearts from animals drinking ethanol showed improved functional recovery and decreased myocyte damage when compared with controls. Adenosine A1 receptor blockade abolished the protection provided by ethanol consumption. These findings indicate that long-term alcohol consumption reduces myocardial ischemia-reperfusion injury and that adenosine A1 receptors are required for this protective effect of ethanol. This cardioprotective effect of long-term alcohol consumption mimics preconditioning and may, in part, account for the beneficial effect of moderate drinking on cardiac health.
M Miyamae; I Diamond; M W Weiner; S A Camacho; V M Figueredo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  94     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3235-9     Citation Subset:  IM    
Department of Medicine (Cardiology), University of California, San Francisco 94110, USA.
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MeSH Terms
Alcohol Drinking*
Creatine Kinase / metabolism
Ethanol / pharmacology*
Guinea Pigs
Ischemic Preconditioning, Myocardial*
Myocardial Ischemia / prevention & control*
Myocardial Reperfusion Injury / prevention & control*
Myocardium / enzymology,  metabolism
Receptors, Purinergic P1 / metabolism
Grant Support
KO8-02448//PHS HHS; KO8-02883//PHS HHS; R01-AG10897/AG/NIA NIH HHS
Reg. No./Substance:
0/Receptors, Purinergic P1; 64-17-5/Ethanol; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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