| Regular aerobic exercise training improves endothelium-dependent arterial dilation in patients with subclinical hypothyroidism. | |
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MedLine Citation:
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PMID: 19737872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Impairment of flow-mediated endothelium-dependent arterial dilation (FMD) exists in patients with subclinical hypothyroidism (sHT). Several studies showed that exercise training can improve FMD in patients with type 1 and type 2 diabetes. Therefore, we hypothesized that exercise training can also improve FMD in subjects with sHT. The purpose of the study was to test this hypothesis. RESEARCH DESIGN AND METHODS: We selected 30 sedentary women with sHT and 27 sedentary healthy women with euthyroid. All individuals participated in an exercise training of 6 months. Before and after exercise training, high resolution ultrasound was used to measure FMD. RESULTS: At baseline, FMD among subjects with sHT was 3.87%, which was significantly lower than that in controls (5.98%; P<0.001). After 6 months of exercise, there was a remarkable increase in FMD (31.3%) and VO(2) max (36.7%; P<0.01), and significant decreases in total cholesterol (20%), low-density lipoprotein cholesterol (LDL; 29%), triglycerides (TG; 47.6%), and C-reactive protein (CRP; 61.5%; P<0.05) were observed over the exercise in patients with sHT. The absolute changes in FMD showed significant correlation with changes in LDL (r=-0.596), TG (r=-0.532), and CRP (r=-0.511; P<0.01), and multiple regression analysis showed changes of LDL, TG, CRP were significant determinants of changes of FMD in sHT patients during exercise course. CONCLUSION: Regular aerobic exercise improves FMD in sHT patients, and changes of lipids and inflammation during the exercise period may partially contribute to the improvement of endothelial function. |
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Authors:
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Guang-da Xiang; Jinhui Pu; Huiling Sun; Linshuang Zhao; Ling Yue; Jie Hou |
Publication Detail:
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Type: Journal Article Date: 2009-09-08 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 161 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-16 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 755-61 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, People's Republic of China. guangda64@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose / metabolism Brachial Artery / physiopathology*, ultrasonography C-Reactive Protein / metabolism Cholesterol / blood Endothelium, Vascular / physiopathology* Exercise / physiology* Female Humans Hypothyroidism / blood, physiopathology*, therapy* Linear Models Middle Aged Oxygen Consumption / physiology Thyroxine / blood Triglycerides / blood Triiodothyronine / blood Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9007-41-4/C-Reactive Protein |
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