Document Detail

Regular aerobic exercise training improves endothelium-dependent arterial dilation in patients with subclinical hypothyroidism.
MedLine Citation:
PMID:  19737872     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Impairment of flow-mediated endothelium-dependent arterial dilation (FMD) exists in patients with subclinical hypothyroidism (sHT). Several studies showed that exercise training can improve FMD in patients with type 1 and type 2 diabetes. Therefore, we hypothesized that exercise training can also improve FMD in subjects with sHT. The purpose of the study was to test this hypothesis. RESEARCH DESIGN AND METHODS: We selected 30 sedentary women with sHT and 27 sedentary healthy women with euthyroid. All individuals participated in an exercise training of 6 months. Before and after exercise training, high resolution ultrasound was used to measure FMD. RESULTS: At baseline, FMD among subjects with sHT was 3.87%, which was significantly lower than that in controls (5.98%; P<0.001). After 6 months of exercise, there was a remarkable increase in FMD (31.3%) and VO(2) max (36.7%; P<0.01), and significant decreases in total cholesterol (20%), low-density lipoprotein cholesterol (LDL; 29%), triglycerides (TG; 47.6%), and C-reactive protein (CRP; 61.5%; P<0.05) were observed over the exercise in patients with sHT. The absolute changes in FMD showed significant correlation with changes in LDL (r=-0.596), TG (r=-0.532), and CRP (r=-0.511; P<0.01), and multiple regression analysis showed changes of LDL, TG, CRP were significant determinants of changes of FMD in sHT patients during exercise course. CONCLUSION: Regular aerobic exercise improves FMD in sHT patients, and changes of lipids and inflammation during the exercise period may partially contribute to the improvement of endothelial function.
Guang-da Xiang; Jinhui Pu; Huiling Sun; Linshuang Zhao; Ling Yue; Jie Hou
Publication Detail:
Type:  Journal Article     Date:  2009-09-08
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  161     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  755-61     Citation Subset:  IM    
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, People's Republic of China.
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MeSH Terms
Blood Glucose / metabolism
Brachial Artery / physiopathology*,  ultrasonography
C-Reactive Protein / metabolism
Cholesterol / blood
Endothelium, Vascular / physiopathology*
Exercise / physiology*
Hypothyroidism / blood,  physiopathology*,  therapy*
Linear Models
Middle Aged
Oxygen Consumption / physiology
Thyroxine / blood
Triglycerides / blood
Triiodothyronine / blood
Vasodilation / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 57-88-5/Cholesterol; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9007-41-4/C-Reactive Protein

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