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Regular Exercise Prevents Sleep Deprivation Associated Impairment of Long-Term Memory and Synaptic Plasticity in The CA1 Area of the Hippocampus.
MedLine Citation:
PMID:  23633758     Owner:  NLM     Status:  In-Data-Review    
STUDY OBJECTIVES: The present study aimed to investigate the effects of treadmill exercise on sleep deprivation (S-D)-induced impairment of hippocampal dependent long-term memory, late phase long-term potentiation (L-LTP) and its signaling cascade in the cornu ammonis 1 (CA1) area.
EXPERIMENTAL DESIGN: Animals were conditioned to run on treadmills for 4 weeks then deprived of sleep for 24 h using the columns-in-water method. We tested the effect of exercise and/or S-D on behavioral performance using a post-learning paradigm in the radial arm water maze (RAWM) and in vivo extracellular recording in the CA1 area. The levels of L-LTP-related molecules in the CA1 area were then assessed both before and after L-LTP induction.
MEASUREMENTS AND RESULTS: After 24 h of S-D, spatial long-term memory impairment in the RAWM and L-LTP suppression was prevented by 4 weeks of regular exercise. Regular exercise also restored the S-D-associated decreases in the basal levels of key signaling molecules such as: calcium/calmodulin kinase IV (CaMKIV), mitogen-activated protein kinase (MAPK/ERK), phosphorylated cAMP response element-binding protein (P-CREB) and brain derived neurotrophic factor (BDNF), in the CA1 area. After L-LTP induction, regular exercise also prevented the S-D-induced down regulation of BDNF and P-CREB protein levels.
CONCLUSIONS: The results suggest that our exercise protocol may prevent 24-h S-D-induced impairments in long-term memory and LTP by preventing deleterious changes in the basal and post-stimulation levels of P-CREB and BDNF associated with S-D. CITATION: Zagaar M; Dao A; Levine A; Alhaider I; Alkadhi K. Regular exercise prevents sleep deprivation associated impairment of long-term memory and synaptic plasticity in the CA1 area of the hippocampus. SLEEP 2013;36(5):751-761.
Munder Zagaar; An Dao; Amber Levine; Ibrahim Alhaider; Karim Alkadhi
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Publication Detail:
Type:  Journal Article     Date:  2013-05-01
Journal Detail:
Title:  Sleep     Volume:  36     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2013  
Date Detail:
Created Date:  2013-05-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  751-61     Citation Subset:  IM    
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, TX.
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