Document Detail

Regular daily intake of black tea improves oxidative stress biomarkers and decreases serum C-reactive protein levels in type 2 diabetic patients.
MedLine Citation:
PMID:  20668372     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).
METHODS: Forty-six patients with known T2DM were randomly assigned either to the test (n = 23, 57.0 +/- 7.9 years) or the control (n = 23, 55.4 +/- 8.3 years) group. Following a one-week 'run-in' period, the test group received 150, 300, 450 and 600 ml of black tea extract (BTE) during the weeks 1, 2, 3 and 4, respectively. The control group received 150 ml BTE a day throughout the intervention period. Dietary, anthropometric and biochemical assessments were performed at the end of each week.
FINDINGS: Serum total antioxidant capacity was enhanced similarly in both test and control groups. However, daily intake of 2 cups of BTE by the test group showed a suppressing effect on serum malondialdehyde. Serum C-reactive protein significantly decreased and glutathione levels increased following the intake of 4 cups (600 ml) of BTE a day.
CONCLUSION: Regular intake of BTE had anti-oxidative and anti-inflammatory effects in patients with T2DM. These findings may, to some extent, explain the mechanisms underlying the protective effects of drinking tea against cardiovascular disease.
Tirang R Neyestani; Nastaran Shariatzade; Ali Kalayi; A'azam Gharavi; Niloufar Khalaji; Monireh Dadkhah; Telma Zowghi; Homa Haidari; Sakineh Shab-bidar
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-07-29
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  57     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  40-9     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Antioxidants / metabolism
Biological Markers
C-Reactive Protein / drug effects*
Camellia sinensis / chemistry
Diabetes Mellitus, Type 2 / drug therapy*
Malondialdehyde / blood
Middle Aged
Oxidative Stress / drug effects*
Plant Extracts / pharmacology*
Tea / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Plant Extracts; 0/Tea; 542-78-9/Malondialdehyde; 9007-41-4/C-Reactive Protein

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