Document Detail

Regular CPAP utilization reduces nasal inflammation assessed by nasal cytology in obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  22763015     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To analyze nasal inflammation in a group of patients with obstructive sleep apnea syndrome (OSAS) by means of nasal cytology and to describe the changes induced by continuous positive air pressure (CPAP) treatment.
SUBJECTS AND METHODS: Thirty-two consecutive patients affected by OSAS (mean age 46.9 years) and 13 control subjects (mean age 49.1 years) were enrolled. Detailed clinical, laboratory, and polysomnographic studies were obtained in all participants and, in particular, nasal cytology was performed; inflammatory cells (neutrophils, eosinophils, mast cells, lymphocytes), bacteria, and spores were counted. A subgroup of 19 OSAS patients underwent regular nasal CPAP for eight weeks while the remaining 13 were noncompliant. Nasal cytology was repeated after eight weeks in all patients and controls.
RESULTS: All patients with OSAS were affected by some form of rhinopathy, mostly subclinical, which was not found to influence compliance to CPAP. Regular CPAP treatment induced a significant reduction of cell infiltration (neutrophils, eosinophils, lymphocytes, and muciparous cells), which was not seen in nontreated patients.
CONCLUSION: Nasal inflammation/infection is a very frequent finding in OSAS and can be reverted by the regular use of CPAP.
Matteo Gelardi; Giuseppe Carbonara; Enrico Maffezzoni; Maurizio Marvisi; Nicola Quaranta; Raffaele Ferri
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Publication Detail:
Type:  Journal Article     Date:  2012-07-02
Journal Detail:
Title:  Sleep medicine     Volume:  13     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-12-03     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  859-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy.
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MeSH Terms
Case-Control Studies
Continuous Positive Airway Pressure*
Inflammation / pathology,  therapy*
Middle Aged
Nasal Mucosa / cytology,  pathology*
Skin Tests
Sleep Apnea, Obstructive / pathology,  therapy*
Comment In:
Sleep Med. 2013 Jun;14(6):581   [PMID:  23628240 ]
Sleep Med. 2013 Jun;14(6):581-2   [PMID:  23410763 ]

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