Document Detail


Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging.
MedLine Citation:
PMID:  23025811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men and women without overt clinical disease. Compared with young adult controls (age=24±1 years, n=29; values are means±S.E.M.), brachial artery FMD (flow-mediated dilation), a measure of conduit artery EDD (endothelium-dependent dilation), was 33% lower [7.93±0.33 against 5.27±0.37%Δ (% change), P<0.05] in MA/O (middle-aged/older) adults with NFG (normal fasting plasma glucose) (≤99 mg/dl, 62±1 years, n=35). In MA/O adults with IFG (100-125 mg/dl, 64±1 years, n=28), FMD was 30% lower (3.37±0.35%Δ) than in their peers with NFG and 58% lower than young controls (P<0.05). Brachial artery FMD was greater (6.38±0.35%Δ) in MA/O adults with NFG who regularly performed aerobic exercise (>45 min/day for ≥5 days/week, 62±1 years, n=23) compared with their non-exercising peers and only slightly less than young controls (P<0.05). Most importantly, FMD was completely preserved in MA/O adults with IFG who regularly performed aerobic exercise (6.99±0.69%Δ, 65±1 years, n=16). In the pooled sample, fasting plasma glucose was inversely related to FMD (r=-0.42, P<0.01) and was the strongest independent predictor of FMD (R(2)=0.32). Group differences in FMD were not affected by other subject characteristics or brachial artery properties, including brachial artery dilation to sublingual NTG (nitroglycerine, i.e. endothelium-independent dilation). IFG exacerbates age-associated vascular endothelial dysfunction and this adverse effect is completely prevented in MA/O adults who regularly perform aerobic exercise.
Authors:
Allison E DeVan; Iratxe Eskurza; Gary L Pierce; Ashley E Walker; Kristen L Jablonski; Rachelle E Kaplon; Douglas R Seals
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  124     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-01-24     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Affiliation:
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. allison.devan@colorado.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aging / physiology*
Blood Glucose / metabolism*
Brachial Artery / physiology
Cardiovascular Diseases / metabolism,  physiopathology*,  prevention & control*
Cohort Studies
Databases, Factual / statistics & numerical data
Endothelium, Vascular / metabolism,  physiopathology*
Exercise / physiology*
Fasting / physiology
Female
Humans
Insulin / blood
Male
Middle Aged
Physical Fitness / physiology
Prediabetic State / metabolism,  physiopathology,  prevention & control
Regional Blood Flow / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
AG000279/AG/NIA NIH HHS; AG013038/AG/NIA NIH HHS; AG031617/AG/NIA NIH HHS; AG033994/AG/NIA NIH HHS; F31 AG033994/AG/NIA NIH HHS; R37 AG013038/AG/NIA NIH HHS; RR00051/RR/NCRR NIH HHS; TR000154/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin
Comments/Corrections
Comment In:
Clin Sci (Lond). 2013 Jul;125(1):55-6   [PMID:  23368887 ]
Clin Sci (Lond). 2013 Jul;125(1):53-4   [PMID:  23356251 ]

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