Document Detail

Regrowth of severed axons in the neonatal central nervous system: establishment of normal connections.
MedLine Citation:
PMID:  472734     Owner:  NLM     Status:  MEDLINE    
When pyramidal tract axons are cut in the adult hamster, fibers degenerate in both anterograde and retrograde directions from the lesion. If the same operation is performed on infant hamsters, however, there is massive regrowth of the severed axons via a new brainstem pathway to their appropriate terminal sites in the medulla and spinal cord. In contrast to previous studies, these results suggest that axons in the mammalian central nervous system damaged early in life may regenerate in a functionally useful way.
K Kalil; T Reh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  205     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1158-61     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Newborn / physiology*
Axons / physiology
Behavior, Animal / physiology
Brain Stem / growth & development
Functional Laterality
Nerve Regeneration*
Neural Pathways / growth & development
Pyramidal Tracts / growth & development*
Spinal Cord / growth & development

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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