| Regret graphs, diagnostic uncertainty and Youden's Index. | |
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MedLine Citation:
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PMID: 8783436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regret is the difference in outcome between the action we took and the best action we could, in retrospect, have taken. 'Tent graphs', representing decision problems under uncertainty in terms of expected regret, offer an instructive geometric supplement to standard formulae, allow instant calculations, and suggest, as we shall illustrate, novel algebraic properties. For instance, the problem of finding the pre-test probability range in which it is worthwhile doing a diagnostic test becomes trivial, even when test costs depend on the unknown disease status; we take the opportunity to explore the (non-trivial) algebraic properties of this problem. The graphs also provide a simple way to illustrate and read off the expected value of information and expected value of perfect information. This property is used to derive a clinical interpretation of Youden's Index (sensitivity + specificity - 1), namely, it is the maximum proportional reduction in expected regret achieved by the test. Finally, we examine the relationship between Youden's Index and the area under an ROC curve. |
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Authors:
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J Hilden; P Glasziou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Statistics in medicine Volume: 15 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 969-86 Citation Subset: IM |
Affiliation:
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Department of Biostatistics, Panum Institut, Copenhagen N, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biometry Decision Support Techniques* Humans Linear Models Male Models, Statistical Probability* ROC Curve Sensitivity and Specificity |
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