| Regression of pulmonary arteriovenous malformations following heart transplantation. | |
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MedLine Citation:
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PMID: 11079267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary arteriovenous malformations (PAVMs) can occur following caval to pulmonary artery connection, Glenn and/or Fontan procedure, leading to severe cyanosis and exercise intolerance. It is unknown whether these abnormalities regress or persist following heart transplantation (HTx). Twenty patients with failed Fontan or Glenn procedures were screened for PAVMs prior to HTx by contrast echocardiography, selective pulmonary angiography, and pulmonary venous desaturation. Age at transplant, diagnosis, previous operations, time from Glenn to transplant, systemic oxygenation, hemoglobin level, and ventricular function were determined. The clinical course after HTx was characterized in three patients with significant PAVMs. Indications for HTx were exercise intolerance and severe cyanosis in one patient, and cyanosis and ventricular dysfunction in two. Pre-HTx, mean systemic saturation was 67%; mean pulmonary venous wedge saturation was 81%. Post-HTx, oxygen saturations were normal (> 96%) at 14, 40, and 180 days. Contrast echocardiography, performed 1 month to 3.3 yrs after HTx, showed no intrapulmonary shunting in two patients and minimal shunting in one. One patient suffered an embolic stroke from right-to-left shunting post-HTx. All patients are alive and well 35, 71, and 73 months post-HTx. In patients with single ventricle physiology, PAVMs are not an absolute contraindication to HTx. Heart-lung transplant may not be required for these patients. |
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Authors:
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J M Lamour; D T Hsu; M R Kichuk; M E Galantowicz; J M Quaegebeur; L J Addonizio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric transplantation Volume: 4 ISSN: 1397-3142 ISO Abbreviation: Pediatr Transplant Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-05-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9802574 Medline TA: Pediatr Transplant Country: DENMARK |
Other Details:
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Languages: eng Pagination: 280-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA. jml14@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriovenous Malformations
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complications* Child Echocardiography Exercise Tolerance Fontan Procedure Heart Defects, Congenital / surgery Heart Transplantation* / methods Humans Oxygen / blood Pulmonary Circulation* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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