Document Detail

Regression of a prolactin-secreting pituitary tumor during long-term treatment with bromocriptine.
MedLine Citation:
PMID:  729834     Owner:  NLM     Status:  MEDLINE    
A nulliparous woman with 12 years of amenorrhea, galactorrhea, and hyperprolactinemia and radiologic evidence of a pituitary macroadenoma was treated with large doses of bromocriptine. During treatment the greatly increased prolactin levels normalized and ovulatory menstrual cycles were regained after 48 weeks of treatment. A transsphenoidal surgical exploration of the pituitary fossa was performed after 27 months of treatment. The findings at surgery suggested that regression of the pituitary adenoma had occurred during the prolonged treatment with bromocriptine. After discontinuation of the therapy, the patient continued to ovulate and subsequently conceived.
S J Nillius; T Bergh; P O Lundberg; J Stahle; L Wide
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  30     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  710-2     Citation Subset:  IM    
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MeSH Terms
Adenoma / complications,  drug therapy*,  secretion
Amenorrhea / etiology
Bromocriptine / therapeutic use*
Galactorrhea / etiology
Pituitary Neoplasms / complications,  drug therapy*,  secretion
Prolactin / blood
Reg. No./Substance:
25614-03-3/Bromocriptine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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