Document Detail

Regression of paroxysmal atrial fibrillation associated with thiazolidinedione therapy.
MedLine Citation:
PMID:  17400309     Owner:  NLM     Status:  MEDLINE    
Thiazolidinediones (TZDs) represent insulin-sensitizing agents that have several pleiotropic properties, possibly related to their favorable effects on cardiovascular remodeling. We briefly describe 2 diabetic patients who experienced a remarkable improvement in their paroxysmal atrial fibrillation (AF) after treatment with rosiglitazone. Current evidence suggests that atrial remodeling represents a prominent mechanism of AF development and perpetuation while inflammation and oxidative stress are possibly implicated in this process. It could therefore be speculated that the pleiotropic effects of TZDs favorably affect atrial remodeling reducing the arrhythmia burden. Further studies are needed in order to elucidate the merit of this pharmacological approach in AF.
Panagiotis Korantzopoulos; Stelios Kokkoris; Evaggelos Kountouris; Ioannis Protopsaltis; Konstantinos Siogas; Andreas Melidonis
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Publication Detail:
Type:  Case Reports; Letter     Date:  2007-04-02
Journal Detail:
Title:  International journal of cardiology     Volume:  125     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e51-3     Citation Subset:  IM    
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MeSH Terms
Atrial Fibrillation / prevention & control*
Diabetes Mellitus, Type 2 / drug therapy
Hypoglycemic Agents / therapeutic use*
Middle Aged
Thiazolidinediones / therapeutic use*
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Thiazolidinediones; 122320-73-4/rosiglitazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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