| Regression of paroxysmal atrial fibrillation associated with thiazolidinedione therapy. | |
MedLine Citation:
|
PMID: 17400309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thiazolidinediones (TZDs) represent insulin-sensitizing agents that have several pleiotropic properties, possibly related to their favorable effects on cardiovascular remodeling. We briefly describe 2 diabetic patients who experienced a remarkable improvement in their paroxysmal atrial fibrillation (AF) after treatment with rosiglitazone. Current evidence suggests that atrial remodeling represents a prominent mechanism of AF development and perpetuation while inflammation and oxidative stress are possibly implicated in this process. It could therefore be speculated that the pleiotropic effects of TZDs favorably affect atrial remodeling reducing the arrhythmia burden. Further studies are needed in order to elucidate the merit of this pharmacological approach in AF. |
Authors:
|
Panagiotis Korantzopoulos; Stelios Kokkoris; Evaggelos Kountouris; Ioannis Protopsaltis; Konstantinos Siogas; Andreas Melidonis |
Related Documents
:
|
8435549 - Treating non-insulin-dependent diabetes. oral agents or insulin? 16952199 - Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 dia... 19125899 - Nateglinide and glibenclamide metabolic effects in naïve type 2 diabetic patients treat... 16647909 - Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin. 18793589 - Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl pe... 19888409 - Impact of treatment with rosiglitazone or metformin on biomarkers for insulin resistanc... 17315049 - Sitagliptin: profile of a novel dpp-4 inhibitor for the treatment of type 2 diabetes. 14749269 - Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of... 3916369 - The antilipemic effectiveness of pentaerythritol tetranicotinate on hyperlipidemic pati... |
Publication Detail:
|
Type: Case Reports; Letter Date: 2007-04-02 |
Journal Detail:
|
Title: International journal of cardiology Volume: 125 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-03-31 Completed Date: 2008-05-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: e51-3 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Atrial Fibrillation
/
prevention & control* Diabetes Mellitus, Type 2 / drug therapy Female Humans Hypoglycemic Agents / therapeutic use* Male Middle Aged Thiazolidinediones / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Hypoglycemic Agents; 0/Thiazolidinediones; 122320-73-4/rosiglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simultaneous hemodynamic and serological cardiotoxicity monitoring during immunotherapy with trastuz...
Next Document: Comment on the article by Vázquez and Márquez-Garcia. High-risk vs. low-risk for thrombo-embolic eve...