| Regression of the nephrotic syndrome in rheumatoid arthritis and amyloidosis treated with azathioprine. A case report. | |
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MedLine Citation:
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PMID: 8849359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary or reactive (AA) amyloidosis is a well-known complication of certain rheumatic diseases, particularly rheumatoid arthritis (RA). This case report describes a patient with RA complicated by amyloidosis and the nephrotic syndrome, which regressed after treatment with azathioprine. The AA amyloidosis was documented by renal and lymph node biopsies and by the presence of proteinuria. Evaluation for other etiologies of proteinuria was negative. After treatment with azathioprine, the proteinuria resolved and the serum albumin level increased from 1.9 mg/dl to normal. This is the first published report of azathioprine therapy resulting in a reversal of the nephrotic syndrome in a patient with RA and secondary amyloidosis. |
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Authors:
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D L Shapiro; H Spiera |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 38 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-10-22 Completed Date: 1996-10-22 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1851-4 Citation Subset: AIM; IM |
Affiliation:
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Mount Sinai School of Medicine, New York, New York 10029-6574, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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etiology* Antirheumatic Agents / therapeutic use* Arthritis, Rheumatoid / complications, drug therapy* Azathioprine / therapeutic use* Female Humans Middle Aged Nephrotic Syndrome / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 446-86-6/Azathioprine |
| Comments/Corrections | |
Comment In:
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Arthritis Rheum. 1996 Nov;39(11):1932-4
[PMID:
8912520
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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