Document Detail

Regression models and risk estimation for mixed discrete and continuous outcomes in developmental toxicology.
MedLine Citation:
PMID:  10949415     Owner:  NLM     Status:  MEDLINE    
Multivariate dose-response models have recently been proposed for developmental toxicity data to simultaneously model malformation incidence (a binary outcome), and reductions in fetal weight (a continuous outcome). In this and other applications, the binary outcome often represents a dichotomization of another outcome or a composite of outcomes, which facilitates analysis. For example, in Segment II developmental toxicology studies, multiple malformation types (i.e., external, visceral, skeletal) are evaluated on each fetus; malformation status may also be ordinally measured (e.g., normal, signs of variation, full malformation). A model is proposed is for fetal weight and multiple malformation variables measured on an ordinal scale, where the correlations between the outcomes and between the offspring within a litter are taken into account. Fully specifying the joint distribution of outcomes within a litter is avoided by specifying only the distribution of the multivariate outcome for each fetus and using generalized estimating equation methodology to account for correlations due to litter clustering. The correlations between the outcomes are required to characterize joint risk to the fetus, and are therefore a focus of inference. Dose-response models and their application to quantitative risk assessment are illustrated using data from a recent developmental toxicology experiment of ethylene oxide in mice.
M M Regan; P J Catalano
Related Documents :
1637985 - Generalized linear models with random effects; salamander mating revisited.
18564995 - Model averaging in microbial risk assessment using fractional polynomials.
15032795 - Testing for marginal independence between two categorical variables with multiple respo...
21830705 - Non-timber forest product harvest in variable environments: modeling the effect of harv...
24109695 - Development of a smart backboard system for real-time feedback during cpr chest compres...
20873515 - Supervision by the dutch healthcare inspectorate.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Risk analysis : an official publication of the Society for Risk Analysis     Volume:  20     ISSN:  0272-4332     ISO Abbreviation:  Risk Anal.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-18     Completed Date:  2000-09-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109978     Medline TA:  Risk Anal     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-76     Citation Subset:  IM    
Biometrics Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / etiology
Dose-Response Relationship, Drug
Models, Biological
Outcome Assessment (Health Care)
Regression Analysis*
Risk Assessment*
Teratogens / toxicity
Teratology / statistics & numerical data*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Salient value similarity, social trust, and risk/benefit perception
Next Document:  Quantitative methods for environmental justice assessment of transportation