| Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase. | |
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MedLine Citation:
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PMID: 20980978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated urinary albumin excretion in patients with type 1 diabetes reverts to normoalbuminuria in a majority of patients but advances toward proteinuria in some. In order to gain valuable insights into the early pathophysiology of diabetic nephropathy we evaluated the association of kidney tubular injury biomarkers with changes in albuminuria in patients with type 1 diabetes mellitus. Urine levels of kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and some inflammatory markers were determined in 38 healthy individuals and 659 patients with type 1 diabetes mellitus having varying degrees of albuminuria. Urinary interleukin-6, CXCL10/IP-10, NAG, and KIM-1 levels were very low in healthy individuals, increased in type 1 patients with normoalbuminuria, and were highest in diabetic patients that had microalbuminuria. Low baseline concentrations of urinary KIM-1 and NAG both individually and collectively were significantly associated with the regression of microalbuminuria over the subsequent 2 years; an effect independent of clinical characteristics. Progression and regression of microalbuminuria were unrelated to urinary levels of interleukins 6 and 8, CXCL10/IP-10, and monocyte chemoattractant protein-1. Thus our results show that lower urinary KIM-1 and NAG levels were associated with the regression of microalbuminuria in type 1 diabetes mellitus. Hence, tubular dysfunction is a critical component of the early course of diabetic nephropathy. |
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Authors:
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Vishal S Vaidya; Monika A Niewczas; Linda H Ficociello; Amanda C Johnson; Fitz B Collings; James H Warram; Andrzej S Krolewski; Joseph V Bonventre |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-27 |
Journal Detail:
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Title: Kidney international Volume: 79 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-05-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 464-70 Citation Subset: IM |
Affiliation:
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Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosaminidase
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urine* Adult Albuminuria / complications*, urine* Biological Markers / urine Case-Control Studies Chemokine CCL2 / urine Chemokine CXCL10 / urine Cross-Sectional Studies Diabetes Mellitus, Type 1 / complications*, urine* Diabetic Nephropathies / physiopathology, urine* Disease Progression Female Follow-Up Studies Humans Inflammation Mediators / urine Interleukin-6 / urine Interleukin-8 / urine Male Membrane Glycoproteins / urine* Middle Aged Receptors, Virus Remission, Spontaneous |
| Grant Support | |
ID/Acronym/Agency:
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DK41526/DK/NIDDK NIH HHS; DK67638/DK/NIDDK NIH HHS; DK72381/DK/NIDDK NIH HHS; DK74099/DK/NIDDK NIH HHS; ES016723/ES/NIEHS NIH HHS; R00 ES016723-03S1/ES/NIEHS NIH HHS; R00 ES016723-04/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CCL2 protein, human; 0/CXCL10 protein, human; 0/Chemokine CCL2; 0/Chemokine CXCL10; 0/HAVCR1 protein, human; 0/IL6 protein, human; 0/IL8 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Interleukin-8; 0/Membrane Glycoproteins; 0/Receptors, Virus; EC 3.2.1.52/Acetylglucosaminidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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