| Regression of stroke-like lesions in MELAS-syndrome after seizure control. | |
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MedLine Citation:
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PMID: 21059492 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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There are some indications that seizure activity promotes the development of stroke-like episodes, or vice versa, in patients with mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome or other syndromic mitochondrial disorders. A 41-year-old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood-sedimentation rate, myopathy, hyper-gammaglobulinaemia, an iron-metabolism defect, migraine-like headaches, and stroke-like episodes, developed complex partial and generalised seizures at age 32 years. Valproic acid was ineffective but after switching to lamotrigine and lorazepam, she became seizure-free for five years and stroke-like episodes did not recur. Cerebral MRI initially showed enhanced gyral thickening and a non-enhanced T2-hyperintensity over the left parieto-temporo-occipital white matter and cortex and enhanced caudate heads. After two years without seizures, the non-enhanced hyperintense parieto-temporo-occipital lesion had disappeared, being attributed to consequent seizure control. The caudate heads, however, remained hyperintense throughout the observational period. This case indicates that adequate seizure control in a patient with MELAS syndrome may prevent the recurrence of stroke-like episodes and may result in the disappearance of stroke-like lesions on MRI. |
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Authors:
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Josef Finsterer; Peter Barton |
Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 12 ISSN: 1294-9361 ISO Abbreviation: Epileptic Disord Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: France |
Other Details:
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Languages: eng Pagination: 330-4 Citation Subset: IM |
Affiliation:
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Krankenanstalt Rudolfstiftung, Institute of Radiology Urania, Vienna, Austria. fifigs1@yahoo.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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