Document Detail

Regression of left ventricular hypertrophy with isradipine in previously untreated hypertensive patients.
MedLine Citation:
PMID:  8466737     Owner:  NLM     Status:  MEDLINE    
The regression of left ventricular hypertrophy (LVH) is considered a desirable goal of antihypertensive treatment. Isradipine was used as first-line antihypertensive treatment in 15 patients who had mild-to-moderate hypertension and LVH, and who were studied before and after 6 months of treatment. Left ventricular mass and function were assessed by Doppler echocardiography. Systolic and diastolic blood pressure were reduced from 161 +/- 14 mm Hg and 103 +/- 3 mm Hg to 136 +/- 8 mm Hg and 87 +/- 6 mm Hg, respectively (P < .001). The interventricular septal thickness was reduced by 11.9% (P < .001), posterior wall thickness by 11.1% (P < .001), left ventricular end-diastolic diameter by 2%, and left ventricular mass index by 17% (P < .02). In conclusion, 6 months of antihypertensive treatment of mild-to-moderate hypertension with isradipine achieves a significant regression (17%) of LVH.
A J Manolis; G Kolovou; S Handanis; G Athanasopoulos; S Antonopoulos; D V Cokkinos
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  6     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-10     Completed Date:  1993-05-10     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86S-88S     Citation Subset:  IM    
Cardiology Department, Tzanio Hospital, Piraeus, Greece.
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MeSH Terms
Echocardiography, Doppler
Heart Ventricles / ultrasonography
Hypertension / complications,  drug therapy*
Hypertrophy, Left Ventricular / drug therapy*,  etiology,  ultrasonography
Isradipine / therapeutic use*
Middle Aged
Treatment Outcome
Reg. No./Substance:

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