Document Detail


Regression of left ventricular hypertrophy in hypertensive dialyzed uremic patients on long-term antihypertensive therapy.
MedLine Citation:
PMID:  8258965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There have been no studies of the possibility of reversing the left ventricular hypertrophy (LVH) of chronically hemodialyzed hypertensive uremics (HDH) with long-term antihypertensive therapy. We have measured left ventricular sizes of eight (6 male, 2 female, aged 29 to 61 years) HDH with M-mode echocardiography, before and 12, 18 and 24 months after the start of a combined antihypertensive therapy which included ACE-inhibitors, beta-blockers and calcium-antagonists. Pre-treatment values for mean blood pressure (MBP), 116.6 +/- 2.9 mm Hg, end diastolic diameter (EDD), 62.6 +/- 6.6 mm, interventricular septum (IVS), 14.2 +/- 3.0 mm, and left ventricular mass index (LVMi), 239 +/- 61 g/m2, were all significantly higher than those for nine sex- and age-matched hemodialyzed normotensive subjects (HDN) with comparable hemoglobin (Hb) levels. During the antihypertensive treatment, both the systolic and diastolic BP decreased steadily (P = 0.0001; P = 0.0003; ANOVA) and significantly by the third month (P < 0.05; P < 0.01), reaching levels comparable to those of the HDN group after 12 months. At this time the LVMi (204 +/- 67) and the IVS (13.1 +/- 2.7), although both significantly lower than baseline, were still higher than in the HDN group, while the EDD was similar. After 24 months, however, both the IVS (12.3 +/- 3.1) and the LVMi (161 +/- 65) were no longer different from those of the HDN group.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
G Cannella; E Paoletti; R Delfino; G Peloso; S Molinari; G B Traverso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  44     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  881-6     Citation Subset:  IM    
Affiliation:
Divisione di Nefrologia e Dialisi, Ospedale San Martino, Genova, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / therapeutic use*
Blood Pressure
Echocardiography
Female
Humans
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / etiology,  ultrasonography*
Male
Middle Aged
Renal Dialysis*
Uremia / complications,  therapy*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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