| Regression of left ventricular hypertrophy after treatment of hypertension: comparison of directed M-echocardiography with magnetic resonance imaging in quantification of serial mass changes. | |
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MedLine Citation:
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PMID: 12751133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study sought to validate the reliability of serial echocardiographic measurements in detecting left ventricular (LV) hypertrophy regression by using magnetic resonance imaging (MRI) as a reference standard. METHODS AND RESULTS: We studied a small population (n = 20) of patients enrolled in the Prospective Randomized Enalapril Study Evaluating Regression of Ventricular Enlargement (PRESERVE) trial for evaluating LV hypertrophy regression. LV mass was measured by both echocardiography and MRI at baseline and after 1 year. As compared with baseline, systolic and diastolic blood pressures were significantly decreased after 1 year (all P <.05). Echocardiographic technique showed an overestimation of LV mass by 27.6 g at baseline (P =.005) and by 37.1 g after 1 year (P <.001), and there were wide 95% limits of agreement (+/-36.0 g at baseline; and +/-27.6 g after 1 year) when compared with MRI measurement. Significant changes of LV mass from baseline of -20 +/- 22 g (P<.01) and -29 +/- 19 g (P <.01) were detected by using echocardiography and MRI after 1 year, respectively (P =.02), and there were similarly wide limits of agreement for change in LV mass (+/-24.2 g). CONCLUSIONS: Despite the use of careful methodology, echocardiographic measurement of LV mass at a single time point or for serial studies resulted in significant variation in LV mass estimates from measurement using MRI. |
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Authors:
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Hung-Fat Tse; Bernard M Y Cheung; William Ng; John K F Chan; Richard B Devereux; Chu-Pak Lau |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiac failure Volume: 9 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-16 Completed Date: 2003-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Hong Kong, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use* Calcium Channel Blockers / therapeutic use Echocardiography* Enalapril / therapeutic use Female Humans Hypertension / drug therapy* Hypertrophy, Left Ventricular / diagnosis*, prevention & control, ultrasonography Magnetic Resonance Imaging* Male Nifedipine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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