| Regression of increased left ventricular masses in elderly hypertensive patients on lisinopril as assessed by magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 8796677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: We investigated, using magnetic resonance imaging, whether the addition of lisinopril could reduce increased left ventricular (LV) masses in hypertensive patients whose blood pressure was well controlled with nifedipine. METHODS: Fourteen hypertensive patients being treated with nifedipine and having an interventricular septum thickness of more than 12 mm were studied. Half of them were given 5 mg lisinopril, and the others were not. Short-axis images of the left ventricle from the base to the apex were obtained by a standard spin-echo pulse sequence. The entire LV mass was calculated from the area of short-axis slices of the left ventricle multiplied by slice thickness. RESULTS: Blood pressure fell slightly and almost equally in both groups. The LV mass and LV mass index showed a significant decrease in the lisinopril-treated group but not in the control group. CONCLUSION: Results demonstrate the effectiveness of lisinopril in reducing increased LV masses, at least in combination with nifedipine. |
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Authors:
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S Handa; M Hamada; M Ura; S Yoshida; I Nishio |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Academic radiology Volume: 3 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-28 Completed Date: 1996-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 294-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Wakayama Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Animals Antihypertensive Agents / therapeutic use Female Humans Hypertension / complications, drug therapy* Hypertrophy, Left Ventricular / diagnosis*, etiology Lisinopril / therapeutic use* Magnetic Resonance Imaging* Male Nifedipine / therapeutic use Reproducibility of Results Swine Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 83915-83-7/Lisinopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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