Document Detail

Regression of hypertrophy in small resistance vessels.
MedLine Citation:
PMID:  2856775     Owner:  NLM     Status:  MEDLINE    
Many studies have documented regression of left ventricular hypertrophy following blood pressure control by some antihypertensive agents but not by others. To determine whether similar differences in regression of wall thickening also occur in resistance vessels during treatment, matched control groups of spontaneously hypertensive rats (SHR) were treated for 12 weeks with either hydralazine or captopril + hydrochlorothiazide and compared with untreated SHR and Wistar-Kyoto rats (WKY). Perfusion pressure was then determined in the hind-limbs of pithed rats under conditions of constant blood flow (4.0 ml/min) and maximal vasodilatation as an index of thickening (hypertrophy) of resistance vessel walls. Treatment with hydralazine or captopril + hydrochlorothiazide controlled blood pressure equally in SHR but had significantly different effects on both left ventricular hypertrophy and resistance vessels. Perfusion pressure was reduced from 37.4 +/- 0.5 mmHg to 33.9 +/- 0.5 mmHg (P < 0.01) with captopril + hydrochlorothiazide but only marginally to 35.9 +/- 0.3 mmHg with hydralazine (P < 0.05 at some levels of flow and P > 0.05 at others). Left ventricular weight was significantly reduced by captopril + hydrochlorothiazide (2.02 +/- 0.02 versus 2.63 +/- 0.05 mg/g, P < 0.01) but only to 2.44 +/- 0.05 by hydralazine. Significant correlations were found both before and following treatment between perfusion pressure and left ventricular weight (r = 0.59, P < 0.01) but not between either of these two parameters and arterial pressure. Thus, despite equal blood pressure control, thickening of resistance vessel walls regressed more with captopril + hydrochlorothiazide than with hydralazine, suggesting that vascular hypertrophy-like left ventricular hypertrophy is not determined by blood pressure levels alone.
T Sano; R C Tarazi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  3     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1993-08-31     Completed Date:  1993-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S489-91     Citation Subset:  IM    
Research Division, Cleveland Clinic Foundation, Cleveland, Ohio.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Blood Vessels / pathology*
Hypertension / complications*,  drug therapy
Hypertrophy / drug therapy,  pathology
Hypertrophy, Left Ventricular / drug therapy,  pathology
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Antihypertensive Agents

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