Document Detail

Regression of coronary artery disease: the role of plaque biology.
MedLine Citation:
PMID:  8556091     Owner:  NLM     Status:  MEDLINE    
Research has lead to a better understanding of the pathophysiology and history of atherosclerotic heart disease, which has reached epidemic proportions in industrialized countries in this century. Atherosclerosis should be seen as a chronic, protracted process that encompasses complex and dynamic interactions between cellular, biochemical, and biophysical factors in the microcosmos of the arterial vessel wall and blood circulation. In this context, the ultimate consequences of this disease process, namely coronary artery disease, must be seen as the "tip of the iceberg." The most dramatic manifestation of coronary artery disease, the acute coronary syndrome, usually occurs as the result of different forces and factors, which lead to abrupt plaque disruption, rupture, and vessel thrombosis. In contrast, the genesis of this atherosclerotic lesion is a slow process. Despite considerable experimental clinical evidence accrued during the past decade, atherosclerosis remains a complex pathophysiological process that is not fully understood. It is clear, however, that the interaction between the cellular elements of the vessel wall and the circulation are the determinants of atheroma formation. In this regard, the vascular endothelium appears to play a pivotal role because of its strategic location and metabolic activity. Antilipidemic therapy influences the outcome of coronary disease through a variety of mechanisms, including direct and indirect effects on the endothelium.
B K Valle; G A Valle; L Lemberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of critical care : an official publication, American Association of Critical-Care Nurses     Volume:  4     ISSN:  1062-3264     ISO Abbreviation:  Am. J. Crit. Care     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9211547     Medline TA:  Am J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  IM; N    
Department of Medicine, University of Miami School of Medicine, Fla., USA.
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MeSH Terms
Antilipemic Agents / pharmacology,  therapeutic use
Coronary Artery Disease / physiopathology,  therapy*
Diet, Fat-Restricted
Endothelium, Vascular / physiopathology
Middle Aged
Reg. No./Substance:
0/Antilipemic Agents

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