| Regression of cardiac hypertrophy with drug treatment in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 6152298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular hypertrophy is an important complication of essential hypertension. Some antihypertensive drugs have been shown to allow regression of cardiac hypertrophy, both in spontaneously hypertensive rats and in hypertensive patients. Recent results show that the agents which interfere with the functions of the sympathetic nervous system, converting enzyme inhibitors and calcium antagonists are effective in reducing arterial blood pressure and regression of left ventricular hypertrophy. The use of vasodilators and diuretics may under certain circumstances, however, even exacerbate cardiac hypertrophy. Regression of left ventricular hypertrophy in hypertension does not appear to depend solely on reduction of arterial blood pressure. Other factors seem to modulate the myocardial response to antihypertensive treatment. Included among these mechanisms are neural, humoral, haemodynamic and biochemical factors. The available experimental data further suggest that some functional derangements and biochemical changes associated with hypertrophy may be reversed by antihypertensive treatment. There is, however, insufficient experience with human subjects to determine whether a reduction in left ventricular mass is associated with lower incidences of heart failure or mortality than may be achieved by adequate blood pressure control alone. |
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Authors:
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H Ruskoaho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Medical biology Volume: 62 ISSN: 0302-2137 ISO Abbreviation: Med. Biol. Publication Date: 1984 |
Date Detail:
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Created Date: 1985-04-29 Completed Date: 1985-04-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0417300 Medline TA: Med Biol Country: FINLAND |
Other Details:
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Languages: eng Pagination: 263-76 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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therapeutic use Adrenergic beta-Antagonists / therapeutic use Animals Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects Cardiomegaly / drug therapy*, etiology, physiopathology Catecholamines / physiology Collagen / analysis Diuretics / therapeutic use Heart / physiopathology Hemodynamics Humans Hypertension / complications*, physiopathology Methyldopa / therapeutic use Myocardium / analysis Myosins / analysis Ornithine Decarboxylase / metabolism Polyamines / analysis Rats Rats, Inbred SHR Vascular Resistance Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Catecholamines; 0/Diuretics; 0/Polyamines; 0/Vasodilator Agents; 555-30-6/Methyldopa; 9007-34-5/Collagen; EC 3.6.4.1/Myosins; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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