| Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan. | |
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MedLine Citation:
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PMID: 16720057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the effect of candesartan on cardiac left ventricular mass in Japanese patients with that of amlodipine. A total of 40 type 2 diabetic patients with hypertension and left ventricular hypertrophy (LVH) were randomly assigned to receive candesartan (n=20) or amlodipine (n=20). The two treatments when administered for 6 months significantly reduced systolic and diastolic blood pressures (BPs) to a comparable extent. Notably, candesartan significantly reduced left ventricular mass index (LVMI: from 131.5+/-4.5 to 112.1+/-5.9g/m(2), P=0.0009, M+/-S.E.M.), LV posterior wall thickness (PWTd: from 10.3+/-0.3 to 9.1+/-0.3mm, P=0.0052) and interventricular septal thickness (IVSTd: from 10.7+/-0.4 to 9.3+/-0.4mm, P=0.0019) as determined by echocardiography in diastole, but amlodipine treatment did not. LVMI, PWTd and IVSTd were decreased more significantly by the treatment with candesartan than by that with amlodipine (P=0.020, 0.031 and 0.043). The present study thus revealed that candesartan effectively induced regression of LVH in type 2 diabetic patients with hypertension due to effects beyond reduction in BP. |
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Authors:
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Yasunori Iwashima; Mizuho Okada; Masakazu Haneda; Takeshi Yoshida |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-05-23 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 74 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2007-01-30 Revised Date: 2007-12-17 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Yoshida Hospital, 4-Nishi 4-1-2, Asahikawa 070-0054, Japan. iwashima@msb.biglobe.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amlodipine / therapeutic use* Antihypertensive Agents / therapeutic use* Benzimidazoles / therapeutic use* Blood Pressure Cardiomegaly / drug therapy* Diabetes Mellitus, Type 2 / complications* Diabetic Angiopathies / drug therapy* Female Heart Rate Humans Hypertension / drug therapy* Male Middle Aged Patient Selection Tetrazoles / therapeutic use* Ventricular Dysfunction, Left / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 139481-59-7/candesartan; 88150-42-9/Amlodipine |
| Comments/Corrections | |
Comment In:
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Diabetes Res Clin Pract. 2007 Sep;77(3):492-3
[PMID:
17306904
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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