Document Detail

Regression of cardiac hypertrophy in type 2 diabetes with hypertension by candesartan.
MedLine Citation:
PMID:  16720057     Owner:  NLM     Status:  MEDLINE    
This study was designed to compare the effect of candesartan on cardiac left ventricular mass in Japanese patients with that of amlodipine. A total of 40 type 2 diabetic patients with hypertension and left ventricular hypertrophy (LVH) were randomly assigned to receive candesartan (n=20) or amlodipine (n=20). The two treatments when administered for 6 months significantly reduced systolic and diastolic blood pressures (BPs) to a comparable extent. Notably, candesartan significantly reduced left ventricular mass index (LVMI: from 131.5+/-4.5 to 112.1+/-5.9g/m(2), P=0.0009, M+/-S.E.M.), LV posterior wall thickness (PWTd: from 10.3+/-0.3 to 9.1+/-0.3mm, P=0.0052) and interventricular septal thickness (IVSTd: from 10.7+/-0.4 to 9.3+/-0.4mm, P=0.0019) as determined by echocardiography in diastole, but amlodipine treatment did not. LVMI, PWTd and IVSTd were decreased more significantly by the treatment with candesartan than by that with amlodipine (P=0.020, 0.031 and 0.043). The present study thus revealed that candesartan effectively induced regression of LVH in type 2 diabetic patients with hypertension due to effects beyond reduction in BP.
Yasunori Iwashima; Mizuho Okada; Masakazu Haneda; Takeshi Yoshida
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-05-23
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  74     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2007-01-30     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
Department of Internal Medicine, Yoshida Hospital, 4-Nishi 4-1-2, Asahikawa 070-0054, Japan.
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MeSH Terms
Amlodipine / therapeutic use*
Antihypertensive Agents / therapeutic use*
Benzimidazoles / therapeutic use*
Blood Pressure
Cardiomegaly / drug therapy*
Diabetes Mellitus, Type 2 / complications*
Diabetic Angiopathies / drug therapy*
Heart Rate
Hypertension / drug therapy*
Middle Aged
Patient Selection
Tetrazoles / therapeutic use*
Ventricular Dysfunction, Left / drug therapy
Reg. No./Substance:
0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 88150-42-9/Amlodipine; S8Q36MD2XX/candesartan
Comment In:
Diabetes Res Clin Pract. 2007 Sep;77(3):492-3   [PMID:  17306904 ]

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