Document Detail

Regression of atherosclerosis: a review.
MedLine Citation:
PMID:  9122427     Owner:  NLM     Status:  MEDLINE    
In recent years, it has been established in humans that progression of atherosclerosis can be slowed, and in some cases, regressed. This differs from previous decades in which such observations were only considered possible in animals. The emergence of more effective lipid-lowering agents along with aggressive dietary and other lifestyle interventions has brought about this change. Other recent studies, using clinical events as the primary outcome, have shown that both pharmacological and lifestyle interventions decrease cardiovascular morbidity and mortality. With these findings, medical and lifestyle management of coronary disease is taking on an increasingly important role as an alternative to invasive interventions. The optimal pharmacological, dietary or exercise regimen, the relative contribution of each, how to optimally implement these programs in large populations, and their cost effectiveness have yet to be defined. This article explores current research in the area of regression of atherosclerosis in humans.
W D Schell; J N Myers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  39     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-96     Citation Subset:  AIM; IM    
Cardiology Division, Palo Alto Department of Veterans Affairs Medical Center, CA 94304, USA.
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MeSH Terms
Antilipemic Agents / therapeutic use
Arteriosclerosis / physiopathology,  therapy*
Disease Progression
Endothelium, Vascular
Exercise Therapy*
Life Style
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Antilipemic Agents

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