Document Detail

Registration of three-dimensional compound ultrasound scans of the breast for refraction and motion correction.
MedLine Citation:
PMID:  8571465     Owner:  NLM     Status:  MEDLINE    
Use of multiple look directions, that is, compound imaging, has been shown previously to increase detection of specular reflectors and averaging of speckle noise in gray-scale images, often at the expense of spatial resolution and other misregistration errors. In color flow imaging, additional view angles can fill in vessels missed due to Doppler angle dropout and increase quantitative and visual Doppler accuracy by triangulation or a simple peak-frequency-shift combination algorithm. Image registration and unwarping throughout multiple three-dimensional (3D) volume sets should correct for many refraction artifacts, motion between and during compounded image sets and even, possibly, positioning errors between image sets, acquired months apart, to display growth of abnormalities. The registration described here does not provide sufficient accuracy for formation of enhanced coherent apertures, but shows promise in some cases to provide superior compound images and possibly comparisons of current and prior studies. In this study, the breast is stabilized by mild compression between a flat plate and a scanning membrane. Registration and unwarping is performed retrospectively on two separate volumetric data sets by defining pairs of corresponding points and, in some cases, line and plane segments. Three-dimensional linear affine transforms are performed using identified points, lines and planes. 3D nonlinear warped transforms are also possible given adequate numbers of identifiable points. More than two data sets are registered by selecting one as the standard, and registering the remainder to match. The most appropriate algorithm, such as averaging or maximum amplitude, may be used to combine the data sets for display. Significant success has been achieved in compound display of a test object and of the breast in vivo, even when there was relative motion or warping between image sets. In pulse-echo imaging, homologous feature registration for compounding appears to have advantages over mechanically registered compounding methods previously employed in the breast and significant increases in lesion and structural conspicuity are noted due to a reduction in speckle noise. The improvements from compounding in 3D, surface-rendered Doppler imaging of vasculature are striking.
A Moskalik; P L Carson; C R Meyer; J B Fowlkes; J M Rubin; M A Roubidoux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  21     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-01     Completed Date:  1996-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  769-78     Citation Subset:  IM    
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109, USA.
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MeSH Terms
Adenocarcinoma / blood supply*,  ultrasonography
Blood Flow Velocity
Breast / blood supply*
Breast Neoplasms / blood supply*,  ultrasonography
Image Processing, Computer-Assisted / methods*
Phantoms, Imaging
Ultrasonography, Doppler, Color
Ultrasonography, Mammary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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