Document Detail


Regioselectivity-reversal in acylation of 6-azauridine catalyzed by Burkholderia cepacia lipase.
MedLine Citation:
PMID:  21898129     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
3'-O-Stearoylation of 6-azauridine was achieved enzymatically for the first time. Among eight commercially available lipases, that from Burkholderia cepacia displayed a 3'-regioselectivity of 80% towards the acylation of 3-hydroxyl of 6-azauridine. Using an immobilized lipase from Burkholderia cepacia, the 3'-regioselectivities of the acylations could be reversed by lengthening the aliphatic chain of the acyl donors (C2-C18). The possible reason might be the presence of the interaction between the base moiety and the acyl group.
Authors:
Zhao-Yu Wang; Yan-Hong Bi; Min-Hua Zong
Related Documents :
24429979 - Natural nitriles and their metabolism.
20121129 - Role of ceria in oxidative dehydrogenation on supported vanadia catalysts.
14700329 - Hydroformylation of 1-hexene in supercritical carbon dioxide: characterization, activit...
22656049 - Comparative kinetics of thiol oxidation in two distinct free-radical generating systems...
11073609 - Stoichiometric and catalytic oxidations of alkanes and alcohols mediated by highly oxid...
20945539 - Crystalline nanoporous metal oxide thin films by post-synthetic hydrothermal transforma...
7646059 - Enzymatic activities of rat liver cytosol 10-formyltetrahydrofolate dehydrogenase.
17962029 - Multicomponent reactions in fungicide research: the discovery of mandipropamid.
8788599 - Inhibition of tetrahydrobiopterin synthesis reduces nitric oxide production by isolated...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-6
Journal Detail:
Title:  Biotechnology letters     Volume:  -     ISSN:  1573-6776     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Life Science and Chemical Engineering, Huaiyin Institute of Technology, Huai'an, 223003, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Isolation, characterization and docking studies of 2,3-dihydroxybiphenyl 1,2-dioxygenase from an act...
Next Document:  Cell recycling during repeated very high gravity bio-ethanol fermentations using the industrial Sacc...