| Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid. | |
| | |
MedLine Citation:
|
PMID: 20594844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug. |
| | |
Authors:
|
Iontcho R Vlahov; Gregory D Vite; Paul J Kleindl; Yu Wang; Hari Krishna R Santhapuram; Fei You; Stephen J Howard; Soong-Hoon Kim; Francis F Y Lee; Christopher P Leamon |
Related Documents
:
|
10509214 - Preconception counseling and women's compliance with folic acid supplementation. 7275974 - Isolation and characterization of dihydrofolic acid reductase from methotrexate-sensiti... 15253044 - Effect of herbal molluscicides and their combinations on the reproduction of the snail ... 20336004 - The isolated and combined effects of folic acid and synthetic bioactive compounds again... 3343104 - The lipids of chalazia. 4043264 - Purification of human urinary erythropoietin on controlled-pore glass and silicic acid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-08 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-16 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 4578-81 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Endocyte Inc., West Lafayette, IN 47906, USA. ivlahov@endocyte.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / chemical synthesis*, chemistry, pharmacology Cell Line, Tumor Disulfides / chemistry Epothilones / chemical synthesis, chemistry*, pharmacology Folate Receptors, GPI-Anchored / antagonists & inhibitors*, metabolism Folic Acid / chemical synthesis, chemistry*, pharmacology Stereoisomerism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Disulfides; 0/Epothilones; 0/Folate Receptors, GPI-Anchored; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.
Next Document: Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopy...