Document Detail


Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.
MedLine Citation:
PMID:  20594844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug.
Authors:
Iontcho R Vlahov; Gregory D Vite; Paul J Kleindl; Yu Wang; Hari Krishna R Santhapuram; Fei You; Stephen J Howard; Soong-Hoon Kim; Francis F Y Lee; Christopher P Leamon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-08
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4578-81     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Endocyte Inc., West Lafayette, IN 47906, USA. ivlahov@endocyte.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemical synthesis*,  chemistry,  pharmacology
Cell Line, Tumor
Disulfides / chemistry
Epothilones / chemical synthesis,  chemistry*,  pharmacology
Folate Receptors, GPI-Anchored / antagonists & inhibitors*,  metabolism
Folic Acid / chemical synthesis,  chemistry*,  pharmacology
Stereoisomerism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Disulfides; 0/Epothilones; 0/Folate Receptors, GPI-Anchored; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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