Document Detail


Regioselective phosphorylation of branched cyclodextrins with cyclo-mono-mu-imidotriphosphate.
MedLine Citation:
PMID:  15993868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phosphorylation of the branched cyclodextrins, mono-6-O-(alpha-D-glucopyranosyl)cyclomaltohexaose, mono-6-O-(alpha-D-maltosyl)cyclomaltohexaose, mono-6-O-(alpha-D-glucopyranosyl)cyclomaltoheptaose, and mono-6-O-(alpha-D-maltosyl)cyclomaltoheptaose, in aqueous solution by sodium cyclo-mono-mu-imidotriphosphate (cMITP) was examined. In these reactions, only the 2-OH group of a single alpha-D-glucopyranosyl residue of the cyclodextrin ring was phosphorylated, in a maximum yield of 67%. A possible mechanism for the phosphorylation is discussed.
Authors:
Hideko Inoue; Toyohiro Kawashita; Hirokazu Nakayama; Mitsutomo Tsuhako
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carbohydrate research     Volume:  340     ISSN:  0008-6215     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1766-72     Citation Subset:  IM    
Affiliation:
Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan. i-hideko@kobepharma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Carbohydrate Conformation
Chromatography, High Pressure Liquid
Cyclodextrins / chemistry*
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Models, Chemical
Phosphates / chemistry*
Phosphorus Compounds / chemistry*
Phosphorylation
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/Cyclodextrins; 0/Phosphates; 0/Phosphorus Compounds; 0/cyclo-mono-mu-imidotriphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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