| Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study. | |
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MedLine Citation:
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PMID: 17095197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This multi-voxel, phosphorus magnetic resonance spectroscopy ((31)P MRS) study examined the prefrontal cortex (PFC), basal ganglia (BG) and superior temporal (ST) region in 10 children with attention-deficit/hyperactivity disorder (ADHD) and 15 healthy controls. ADHD patients had lower PFC and BG phosphomonoester (PME) levels compared to healthy children. No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD. |
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Authors:
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Jeffrey A Stanley; Heidi Kipp; Erika Greisenegger; Frank P MacMaster; K Panchalingam; Jay W Pettegrew; Matcheri S Keshavan; Oscar G Bukstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-07 |
Journal Detail:
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Title: Psychiatry research Volume: 148 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-02-12 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 217-21 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B-28, 4201 St. Antoine Street, Detroit, MI 48201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Attention Deficit Disorder with Hyperactivity
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diagnosis,
physiopathology* Attention Deficit and Disruptive Behavior Disorders / diagnosis, physiopathology Basal Ganglia / physiopathology* Child Comorbidity Female Humans Magnetic Resonance Spectroscopy* Male Membrane Lipids / metabolism* Nerve Net / physiopathology Neurons / physiology Phospholipids / metabolism* Phosphorus / metabolism Prefrontal Cortex / physiopathology* Synapses / physiology Temporal Lobe / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH065420-JAS/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Phospholipids; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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