Document Detail

Regionally distinct white matter lesions do not contribute to regional gray matter atrophy in patients with multiple sclerosis.
MedLine Citation:
PMID:  20412395     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To determine to what extent T1- and T2-regional lesion volumes (RLVs) contribute to total and/or regional gray matter (GM) atrophy in multiple sclerosis (MS).
METHODS: We studied 110 (67 relapsing-remitting and 43 secondary-progressive) MS patients. SABRE program was used to parcel the brain into 13 regions per hemisphere. Total and regional GM fractions (GMFs) were determined in each region to correct for intraregional size variability. Partial correlations were used to determine associations (holding the converse constant) between RLVs, GMF, and regional GMFs (P < .001 to avoid Type 1 error).
RESULTS: Partial correlations between RLVs and regional GMFs (controlling for total GMF) for the total MS group were not significant for any of the 26 regions for T2, whereas they were significant for two of the 26 regions for T1. Partial correlations between RLVs and total GMF (controlling for regional GMF) for the total MS group were significant in 9 of 26 regions for T2 (largest r = right lateral inferior frontal, -.45) and 5 of 26 regions for T1 (largest r = right inferior parietal, -.45).
CONCLUSIONS: Results suggest a model whereby a distinct generalized disease process accounts for GM atrophy better than regionally distinct Wallerian degeneration.
Ronald Antulov; Dominic A Carone; Jared Bruce; Viritha Yella; Michael G Dwyer; Christopher W Tjoa; Ralph H B Benedict; Robert Zivadinov
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Publication Detail:
Type:  Journal Article     Date:  2010-04-13
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  21     ISSN:  1552-6569     ISO Abbreviation:  J Neuroimaging     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
Copyright Information:
© 2010 by the American Society of Neuroimaging.
From the Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, NY (RA, VY, MGD, CWT, RZ); Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia (RA); State University of New York, Upstate Medical University, Syracuse, NY (DAC); Brown University, Providence, RI (JB); The Jacobs Neurological Institute, Department of Neurology, State University of New York at Buffalo, Buffalo, NY (RHBB, RZ).
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