Document Detail


Regional white matter abnormalities in drug-naive, first-episode schizophrenia Patients and their healthy unaffected siblings.
MedLine Citation:
PMID:  25318995     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Shared neuropathological features between schizophrenia patients and their siblings may represent intermediate phenotypes of schizophrenia and can be used to investigate genetic susceptibility to the illness. This study aimed to discover regional white matter abnormalities in first-episode schizophrenia (FES) patients and their unaffected siblings compared to healthy subjects in the Chinese Han population using optimized Voxel-Based Morphometry (VBM).
METHOD: A total of 51 drug-naive, FES patients, 45 of their unaffected siblings and 59 healthy comparisons were studied with magnetic resonance imaging (MRI).
RESULTS: FES patients exhibited significant regional white matter deficits in the left inferior frontal gyrus and left joint of external capsule and internal capsule compared with healthy subjects (corrected FDR, p<0.005). The sibling group also showed significant white matter deficits in these two regions compared with the healthy comparison group (uncorrected, p<0.001). White matter deficits with a less stringent threshold for significance in the left cerebellum anterior lobe, left middle frontal gyrus, left hippocampus, right anterior cingulate and right internal capsule were observed in patients compared to their siblings.
CONCLUSIONS: Our findings extend those from previous VBM analyses showing that FES patients and their unaffected siblings may share white matter deficits in the left inferior frontal gyrus and the left joint of external capsule and internal capsule. These regional white matter deficits may be related to genetic factors related to schizophrenia susceptibility.
Authors:
Hailong Lyu; Maorong Hu; Lisa T Eyler; Hua Jin; Juan Wang; Jianjun Ou; Xiaofeng Guo; Zhong He; Fang Liu; Jingping Zhao; Wenbin Guo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-15
Journal Detail:
Title:  The Australian and New Zealand journal of psychiatry     Volume:  -     ISSN:  1440-1614     ISO Abbreviation:  Aust N Z J Psychiatry     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-16     Completed Date:  -     Revised Date:  2014-10-17    
Medline Journal Info:
Nlm Unique ID:  0111052     Medline TA:  Aust N Z J Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Royal Australian and New Zealand College of Psychiatrists 2014.
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