| Regional variations of vasomotion to G-protein coupled receptor agonists following heat stress in rats. | |
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MedLine Citation:
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PMID: 20487214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. METHODS: Heat exposure was performed by increasing the internal temperature of the rats to 42 degrees C for 15 min. After heat stress for 48 h, a myograph system was used to monitor the contractile responses in rat renal, femoral and mesenteric arteries to agonists of endothelin type B (ET(B)) receptor, endothelin type A (ET(A)) receptor, serotonin receptor and alpha-adrenoceptor, respectively. In addition, calcitonin gene-related peptide (CGRP)-induced vasodilation was studied. KEY FINDINGS: The results showed that heat stress induced decreased contractions mediated by alpha-adrenoceptors and serotonin receptors (at lower concentration), while it increased contraction mediated by endothelin ET(B) receptors and enhanced relaxation mediated by CGRP receptors in the renal artery. Heat stress increased contractions mediated by endothelin ET(B) receptors, endothelin ET(A) receptors and alpha-adrenoceptors in the femoral artery. In the mesenteric artery, heat stress increased contractions mediated by endothelin ET(B) and serotonin receptors and relaxation mediated by CGRP receptors. CONCLUSIONS: The vasomotor responses to the G-protein coupled receptor agonists with altered vascular contractions and relaxations were different in rat renal, femoral and mesenteric arteries after heat stress. This might have contributed to the redistribution of blood flow and aids understanding of the preconditioning phenomenon. |
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Authors:
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Jie Li; Yong-Xiao Cao; Kun-Lun Chen; Lei Cao; Zhao Ma; Cang-Bao Xu |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 315-22 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, P R China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Animals Arteries / drug effects*, physiopathology Calcitonin Gene-Related Peptide / pharmacology Femoral Artery / drug effects, physiopathology Heat Stress Disorders / physiopathology* Male Mesenteric Arteries / drug effects, physiopathology Muscle, Smooth, Vascular / drug effects*, physiopathology Neurotransmitter Agents / pharmacology* Organ Specificity Osmolar Concentration Rats Rats, Sprague-Dawley Receptors, Endothelin / agonists Receptors, G-Protein-Coupled / agonists* Renal Artery / drug effects, physiopathology Serotonin Receptor Agonists / pharmacology Vasoconstriction / drug effects* Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Neurotransmitter Agents; 0/Receptors, Endothelin; 0/Receptors, G-Protein-Coupled; 0/Serotonin Receptor Agonists; 83652-28-2/Calcitonin Gene-Related Peptide |
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