Document Detail

Regional variations of iodine nutrition and thyroid function during the neonatal period in Europe.
MedLine Citation:
PMID:  3756256     Owner:  NLM     Status:  MEDLINE    
In order to evaluate further the possibility that transient hypothyroidism and hyperthyrotropinemia in newborn infants could result from a state of relative iodine deficiency, the urinary concentration of iodine, used as an index of the dietary intake of iodine was determined in casual urine samples collected in 1,076 full-term infants aged 3-6 days in 16 cities in 10 different European countries and in Toronto, Canada. In addition, the results obtained by programs of systematic neonatal screening for congenital hypothyroidism in the same areas were compared. There were marked regional differences in iodine nutrition during the neonatal period in Europe (median urinary iodine: 16.2 micrograms/dl in Rotterdam, the Netherlands, and 1.1 micrograms/dl in Freiburg, FRG. A low iodine supply in newborn populations was accompanied by, and probably explained, an elevated frequency of transient disorders of thyroid function in young infants. Iodine prophylaxis is urgently needed in some European countries not only for the prevention of goiter, but mostly for the prevention of impairment of thyroid function during the critical period of brain development.
F Delange; P Heidemann; P Bourdoux; A Larsson; R Vigneri; M Klett; C Beckers; P Stubbe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  49     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1986  
Date Detail:
Created Date:  1986-11-18     Completed Date:  1986-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  322-30     Citation Subset:  IM    
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MeSH Terms
Congenital Hypothyroidism
Hypothyroidism / epidemiology*
Infant Nutrition Disorders / epidemiology*,  etiology
Infant Nutritional Physiological Phenomena
Infant, Newborn
Iodine / administration & dosage,  deficiency*,  urine
Mass Screening
Thyroid Function Tests
Thyrotropin / blood
Reg. No./Substance:
7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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