Document Detail


Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats.
MedLine Citation:
PMID:  6748090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Densitometric scanning of SDS-polyacrylamide gels was used to measure myosin heavy chain concentration in left ventricular specimens obtained from cat hearts 3 to 12 months after healing of small experimental myocardial infarctions. The study was designed to test the hypothesis that myosin concentration varies as a function of anatomic proximity to the infarct scar. Myosin heavy chain concentration was elevated in non-scarred areas adjacent to a healed infarct and normal in areas remote from the scar. The scar itself had reduced concentrations, reflecting the loss of muscle mass in this area. The increased myosin heavy chain concentration in regions adjacent to the scar may be an attempt to regulate or compensate for the decrease in mechanical function of the scarred area.
Authors:
P L Kozlovskis; J D Silver; R W Rubin; S S Wong; M S Gaide; A L Bassett; J S Cameron; R J Myerburg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  16     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-07     Completed Date:  1984-09-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  559-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Electrophoresis, Polyacrylamide Gel
Myocardial Infarction / metabolism*,  pathology
Myocardium / pathology
Myosins / metabolism*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
HL 07436/HL/NHLBI NIH HHS; HL 19044/HL/NHLBI NIH HHS; HL 21735/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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