Document Detail


Regional variations in the concentrations of ketone bodies in cirrhosis and hepatic encephalopathy: a study in patients with TIPSS.
MedLine Citation:
PMID:  21457443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little is known about the metabolism of acetoacetate and β-hydroxybutyrate in patients with cirrhosis and encephalopathy.
AIMS: We investigated the fate of ketone bodies in these conditions.
MATERIALS AND METHODS: We studied 18 cirrhotic patients with encephalopathy and 17 cirrhotics without. At the time of insertion of a transjugular intrahepatic portosystemic stent shunt (TIPSS) or at the time of portographical assessment of the shunt's patency, we collected blood from the internal jugular, the right atrium, the inferior vena cava, the hepatic, the portal, the splenic veins and the radial artery. We used nuclear magnetic resonance spectroscopy to measure the concentrations of acetoacetate and β-hydroxybutyrate.
RESULTS: There was no difference in the total ketone body concentrations between the two groups. The mitochondrial redox potential was significantly higher in the encephalopathics (142/54=2.63 vs 52/83=0.62) (P<0.01). β-hydroxybutyrate was significantly lower in the portal vein of encephalopathics (52 ± 4 vs 28 ± 3) (P<0.02) and in the splenic vein (48 ± 6 vs 32 ± 5) (P<0.04). Acetoacetate was significantly higher in encephalopathics in the internal jugular vein (134 ± 12 vs 92 ± 16) (P<0.03), the right atrium (112 ± 18 vs 68 ± 11) (P<0.03), the hepatic vein (162 ± 25 vs 115 ± 19) (P<0.05), the portal vein (133 ± 20 vs 81 ± 14) (P<0.02) and the splenic vein (167 ± 24 vs 122 ± 21) (P<0.04). All measurements are expressed in μmols/L.
CONCLUSIONS: There are significant variations in the regional concentrations of the ketone bodies in encephalopathy.
Authors:
Konstantinos J Dabos; Benjamin A Haughton; Benjamin J Houghton; Emmanouil Pyleris; Doris N Redhead; Peter C Hayes; Ian H Salder; John N Plevris
Related Documents :
872843 - Ophthalmoplegic migraine with persistent abducens nerve palsy.
21422723 - Inhibition of untransformed prostaglandin h(2) production and stretch-induced contracti...
6841463 - Effect of topically administered epinephrine, norepinephrine, and acetylcholine on cere...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-03-06
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  31     ISSN:  1478-3231     ISO Abbreviation:  Liver Int.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-19     Revised Date:  2011-11-25    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  707-11     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Hepatology, University of Edinburgh, Edinburgh, UK. kostasophia@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid / blood*
Acetoacetates / blood*
Adult
Analysis of Variance
Biological Markers / blood
Female
Hepatic Encephalopathy / blood*,  etiology
Humans
Liver / metabolism*
Liver Cirrhosis / blood,  complications,  surgery*
Magnetic Resonance Spectroscopy
Male
Middle Aged
Portasystemic Shunt, Transjugular Intrahepatic*
Scotland
Treatment Outcome
Chemical
Reg. No./Substance:
0/Acetoacetates; 0/Biological Markers; 300-85-6/3-Hydroxybutyric Acid; 541-50-4/acetoacetic acid
Comments/Corrections
Erratum In:
Liver Int. 2011 Sep;31(8):1242
Note: Houghton, Benjamin J [corrected to Haughton, Benjamin A]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and cor...
Next Document:  Validity of administrative data for the diagnosis of primary sclerosing cholangitis: a population-ba...