Document Detail


Regional uptake of meal fatty acids in humans.
MedLine Citation:
PMID:  12915396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two protocols were performed to study meal fatty acid metabolism. In protocol 1, 14 patients scheduled for elective intra-abdominal surgery (11 undergoing bariatric surgery for severe obesity) consumed a meal containing [3H]triolein in the evening before surgery. This allowed us to measure adipose tissue lipid specific activity (SA) in mesenteric and omental, deep and superficial abdominal subcutaneous adipose tissue. Intra-abdominal adipose tissue lipid SA was greater than subcutaneous lipid SA. There were no significant differences between mesenteric and omental or between deep and superficial abdominal subcutaneous adipose tissue. In protocol 2, meal fatty acid oxidation and uptake into subcutaneous and omental adipose tissue ([3H]triolein) were measured in six normal, healthy volunteers. Meal fatty acid oxidation (3H2O generation) plus that remaining in plasma ( approximately 1%) plus uptake into upper body subcutaneous, lower body subcutaneous, and visceral fat allowed us to account for 98 +/- 6% of meal fatty acids 24 h after meal ingestion. We conclude that omental fat is a good surrogate for visceral fat and that abdominal subcutaneous fat depots are comparable with regard to meal fatty acid metabolic studies. Using [3H]triolein, we were able to account for virtually 100% of meal fatty acids 24 h after meal ingestion. These results support the meal fatty acid tracer model as a way to study the metabolic fate of dietary fat.
Authors:
Michael D Jensen; Michael G Sarr; Daniel A Dumesic; Peter A Southorn; James A Levine
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-08-12
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  285     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-01-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1282-8     Citation Subset:  IM    
Affiliation:
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. jensen.michael@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Blood Glucose / analysis
Dietary Fats / pharmacokinetics*
Fatty Acids, Essential / pharmacokinetics*
Female
Humans
Insulin / blood
Male
Mesentery / metabolism*
Middle Aged
Obesity, Morbid / blood,  metabolism*
Omentum / metabolism*
Organ Specificity
Tissue Distribution
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
DK-45343/DK/NIDDK NIH HHS; DK-50456/DK/NIDDK NIH HHS; RR-0585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Fatty Acids, Essential; 0/Triglycerides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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