Document Detail

Regional transient osteoporosis of the foot and vitamin C deficiency.
MedLine Citation:
PMID:  16538389     Owner:  NLM     Status:  MEDLINE    
We describe the clinical presentation and diagnostic tests of a patient with regional transient osteoporosis (RTO) of the foot. This patient presented with a 4-month history of left-foot pain, nonpitting edema, and brownish discolorations of both feet. He had a history of tobacco abuse, alcohol abuse, and malnutrition. Radiological studies revealed severe osteopenia in the feet, and a MRI revealed bone marrow edema. The bone biopsy was consistent with RTO. This patient also had vitamin C deficiency. This case suggests a link between vitamin C deficiency and RTO, a hypothesis supported by our review of relevant literature on osteoporosis and vitamin C.
Sandra Rodriguez; Oscar Paniagua; Kenneth M Nugent; Michael P Phy
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-03-15
Journal Detail:
Title:  Clinical rheumatology     Volume:  26     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  976-8     Citation Subset:  IM    
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street STOP 9410, Lubbock, TX 79430, USA.
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MeSH Terms
Ascorbic Acid / therapeutic use*
Ascorbic Acid Deficiency / complications*,  physiopathology
Bone Diseases, Metabolic
Dietary Supplements*
Foot Bones / physiopathology,  radiography
Middle Aged
Osteoporosis / etiology*,  physiopathology,  radiography
Reg. No./Substance:
50-81-7/Ascorbic Acid

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