Document Detail

Regional and systemic hemodynamic and humoral effects of transdermal nitroglycerin in mild hypertension.
MedLine Citation:
PMID:  2478778     Owner:  NLM     Status:  MEDLINE    
Venous distensibility, forearm blood flow (FBF, plethysmographic technique), systemic blood pressure (BP), and derived forearm vascular resistances were measured in 11 borderline-mild hypertensive, otherwise healthy male subjects for a 24-h period during either placebo or transdermally delivered nitroglycerin (NTG 10 mg/24 h). The drug caused arteriolar and venular forearm vasodilation and hypotension which, although persisting throughout the 24-h observation period, reached an apparent maximum during the first hours but later tended to wane. Since NTG plasma levels were constant at that time, the data may suggest development of vascular hyporesponsiveness during continuous exposure to NTG. Venous hematocrit (Hct) decreased during transdermal NTG, indicating the plasma volume expanding action of the drug, apparently dissociated from vasodilation per se. Because no significant changes in either plasma norepinephrine (NE) or plasma renin activity occurred in these subjects, counterregulatory sympathetic or angiotensin II (AII)-mediated vasoconstriction was probably not involved in the hemodynamic action of transdermally delivered NTG.
R Pedrinelli; L Graziadei; G Panarace; P Duranti; M Motolese; A Salvetti
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  14     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-29     Completed Date:  1989-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-41     Citation Subset:  IM    
Hypertension Unit I, University of Pisa, Italy.
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MeSH Terms
Administration, Cutaneous
Hemodynamics / drug effects*
Hypertension / physiopathology*
Middle Aged
Nitroglycerin / administration & dosage,  blood,  pharmacology*
Norepinephrine / blood
Regional Blood Flow / drug effects*
Renin / blood
Reg. No./Substance:
51-41-2/Norepinephrine; 55-63-0/Nitroglycerin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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