Document Detail


Regional and systemic hemodynamic and humoral effects of transdermal nitroglycerin in mild hypertension.
MedLine Citation:
PMID:  2478778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Venous distensibility, forearm blood flow (FBF, plethysmographic technique), systemic blood pressure (BP), and derived forearm vascular resistances were measured in 11 borderline-mild hypertensive, otherwise healthy male subjects for a 24-h period during either placebo or transdermally delivered nitroglycerin (NTG 10 mg/24 h). The drug caused arteriolar and venular forearm vasodilation and hypotension which, although persisting throughout the 24-h observation period, reached an apparent maximum during the first hours but later tended to wane. Since NTG plasma levels were constant at that time, the data may suggest development of vascular hyporesponsiveness during continuous exposure to NTG. Venous hematocrit (Hct) decreased during transdermal NTG, indicating the plasma volume expanding action of the drug, apparently dissociated from vasodilation per se. Because no significant changes in either plasma norepinephrine (NE) or plasma renin activity occurred in these subjects, counterregulatory sympathetic or angiotensin II (AII)-mediated vasoconstriction was probably not involved in the hemodynamic action of transdermally delivered NTG.
Authors:
R Pedrinelli; L Graziadei; G Panarace; P Duranti; M Motolese; A Salvetti
Related Documents :
6380878 - Acute hemodynamic and hormonal response to indoramin in congestive heart failure.
2570368 - Methylxanthines augment the renin response to suprarenal-aortic constriction.
11004688 - Malignant hypertension - the role of the paracrine renin-angiotensin system.
7780288 - Smoking induced differences in autonomic responses in military pilot candidates.
12589178 - Sympathetic control of the circulation in hypertension: lessons from autonomic disorders.
12403658 - Endothelin-a receptor blockade prevents left ventricular hypertrophy and dysfunction in...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  14     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-29     Completed Date:  1989-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-41     Citation Subset:  IM    
Affiliation:
Hypertension Unit I, University of Pisa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Hematocrit
Hemodynamics / drug effects*
Humans
Hypertension / physiopathology*
Male
Middle Aged
Nitroglycerin / administration & dosage,  blood,  pharmacology*
Norepinephrine / blood
Regional Blood Flow / drug effects*
Renin / blood
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 55-63-0/Nitroglycerin; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Attenuation of the baroreceptor reflex by propofol anesthesia in the rat.
Next Document:  Effect of verapamil on systemic and brachial artery hemodynamics in normal humans: comparison with e...