Document Detail

Regional specification during cerebellar development.
MedLine Citation:
PMID:  8087538     Owner:  NLM     Status:  MEDLINE    
At early phases of development (stage HH12 of chick and quail embryos) the rostral part of the cerebellar anlage extends into the caudal third of the mesencephalic vesicle. This region is characterized by its high level of expression of the Wnt-1 and engrailed genes, which encode, respectively, for a secreted molecule and for a homeodomain protein. In order to analyze the potentialities of various parts of the cerebellar anlage, pieces of quail or mouse embryonic neural tubes have been transplanted heterotopically in the prosencephalon of HH12 chick embryos. These experiments indicated that signals operating in the plane of the neural tube are still operating in the donor avian and murine embryos. The met- mes- and prosencephalic territories of HH12 chick embryos are still competent to change their fates under the influence of these signals. It was also found that the Wnt-1 expression domain, the caudal mesencephalic vesicle, has striking organizing properties until late stages of development in avian and rodent embryos. The exact role of Wnt-1 in these inductive interactions is still unknown. Wnt-1 influence on cell fate could be mediated by the engrailed genes. Observations suggesting a later role of en-2 in the regionalization of the cerebellar cortex are also reported.
M Wassef; L Bally-Cuif; R M Alvarado-Mallart
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Perspectives on developmental neurobiology     Volume:  1     ISSN:  1064-0517     ISO Abbreviation:  Perspect Dev Neurobiol     Publication Date:  1993  
Date Detail:
Created Date:  1994-10-19     Completed Date:  1994-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417971     Medline TA:  Perspect Dev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
INSERM U106, Hôpital de la Salpêtrière, Paris, France.
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MeSH Terms
Brain Tissue Transplantation
Cell Communication
Cerebellum / abnormalities,  embryology*
Chick Embryo
Coturnix / embryology,  genetics
DNA-Binding Proteins / biosynthesis,  genetics,  physiology
Gene Expression Regulation
Homeodomain Proteins*
Mesencephalon / embryology,  transplantation
Mice / embryology,  genetics
Mice, Transgenic
Morphogenesis / genetics
Nerve Tissue Proteins / biosynthesis,  chemistry,  genetics
Organ Specificity
Proto-Oncogene Proteins / biosynthesis,  genetics,  physiology
Signal Transduction
Species Specificity
Transplantation, Heterologous
Wnt Proteins
Wnt1 Protein
Zebrafish Proteins*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/En1 protein, mouse; 0/Homeodomain Proteins; 0/Nerve Tissue Proteins; 0/Proto-Oncogene Proteins; 0/Wnt Proteins; 0/Wnt1 Protein; 0/Wnt1 protein, mouse; 0/Zebrafish Proteins; 0/engrailed 2 protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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