Document Detail


Regional, segmental, and temporal heterogeneity of cerebral vascular autoregulation.
MedLine Citation:
PMID:  3898928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoregulation of cerebral blood flow is heterogeneous in several ways: regional, segmental, and temporal. We have found regional heterogeneity of the autoregulatory response during both acute reductions and increases in systemic arterial pressure. Changes in blood flow are less in brain stem than in cerebrum during decreases and increases in cerebral perfusion pressure. Segmental heterogeneity of autoregulation has been demonstrated in two ways. Direct determination of segmental cerebral vascular resistance indicates that, while small cerebral vessels (less than 200 micron in diameter) make a major contribution to autoregulation during acute increases in pressure between 80 and 100 mm Hg, the role of large cerebral arteries (greater than 200 micron) becomes increasingly important to the autoregulatory response at pressures above 100 mm Hg. Measurement of changes in diameter of pial vessels has shown that, during acute hypotension, autoregulation occurs predominantly in small resistance vessels (less than 100 micron). Finally, there is temporal heterogeneity of autoregulation. Sudden increases in arterial pressure produce transient increases in blood flow, which are not observed under steady-state conditions. In addition, the blood-brain barrier is more susceptible to hypertensive disruption after rapid, compared to step-wise, increases in arterial pressure. Thus, when investigating cerebral vascular autoregulation, regional, segmental, and temporal differences in the autoregulatory response must be taken into consideration.
Authors:
G L Baumbach; D D Heistad
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  13     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-09     Completed Date:  1985-10-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / physiology
Biomedical Engineering
Blood Pressure
Brain Stem / blood supply
Cats
Cerebral Arteries / physiology
Cerebrovascular Circulation*
Dogs
Homeostasis*
Hypertension / physiopathology
Hypotension / physiopathology
Regional Blood Flow
Vascular Resistance
Grant Support
ID/Acronym/Agency:
HL-14230/HL/NHLBI NIH HHS; HL-14388/HL/NHLBI NIH HHS; HL-16066/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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