Document Detail


Regional renin release by the cat kidney in vitro and in vivo.
MedLine Citation:
PMID:  474759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences in the rate of renin release by superficial and deep areas of the cat kidney cortex were studied in vitro and in vivo. Renin release in vitro by outer cortical slices was significantly higher than by their inner counterparts: 19.6 +/- 2.3 vs. 12.8 +/- 1.95 ng angiotensin I-h-1-mg fresh tissue-1-h of incubation-1. In vivo blood was sampled from subcapsular (outer cortical) and deep (inner cortical and medullary) renal venous circulation from anesthetized cats. Renal venous minus arterial plasma renin concentration was respectively, 4.3 +/- 1.12 and 1.9 +/- 1.04 ng angiotensin I-ml-1-h-1 (P less than 0.01). By assuming that in these experiments renal blood flow distribution was approximately equal to each of the two areas of venous drainage, as reported in the isolated perfused cat kidney, we infer from the regional differences in arteriovenous concentration that the rate of renin release of the outer cortex is higher than that of the innder cortex in the cat kidney in vivo. Tissue content of renin was found to decrease toward the deep cortex. The results support the concept that the rate of regional renin release correlates with tissue renin content, at least under the conditions of the present experiments.
Authors:
S M Jones; J Torretti; J S Williams; S F Weinberger
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F188-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Kidney / blood supply,  secretion*
Kidney Cortex / secretion
Regional Blood Flow
Renin / secretion*
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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