| Regional rates of myocardial fatty acid metabolism: comparison with coronary angiography and ventriculography. | |
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MedLine Citation:
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PMID: 2351168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 50 patients, 1 mCi 123I phenylpentadecanoic acid (IPPA) was injected at peak ergometric stress and 1500 frames were acquired (1 frame/s) with a high count rate gamma camera. Parametric images of rates of decrease and increase for different time intervals after stress were compared with coronary angiography and LV ventriculography, separately evaluating the 3 main coronary territories: 18/150 territories supplied by normal coronaries presented rather homogeneous regional clearing rates, whereas a gradual decrease in clearing rates towards the end of the territory (frequently with peripheral defects) was seen in all 87/150 territories with significant coronary narrowing. In local correspondence to clearing defects, initial IPPA accumulations could be observed with later onset of clearing between 10 and 25 min. 44/150 territories presented abnormal clearing rates, mostly with a patchy pattern, with normal coronary anatomy, but all except one had LV dysfunction and a clinical diagnosis of cardiomyopathy, diabetes mellitus or hypertensive disease. Twenty four of the 41 patients with CAD had, in correspondence to a prior myocardial infarction, minimum or missing metabolic activity frequently in circumscribed zones, partly separated by bridges of still viable tissue with preserved but reduced clearing rates. |
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Authors:
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N Schad; R K Wagner; J Hallermeier; H J Daus; A Vattimo; P Bertelli |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 16 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1990 |
Date Detail:
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Created Date: 1990-07-16 Completed Date: 1990-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM |
Affiliation:
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Lehrkrankenhaus der Technischen Universität München, Passau, Federal Republic of Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Coronary Angiography* Coronary Disease / radiography, radionuclide imaging* Heart / radionuclide imaging Humans Iodine Radioisotopes / diagnostic use Iodobenzenes / diagnostic use* Middle Aged Myocardium / metabolism* Radionuclide Ventriculography |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Iodobenzenes; 80479-93-2/omega-(4-iodophenyl)pentadecanoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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