| Regional pulmonary perfusion using model-free analysis of contrast-enhanced MRI in meconium-aspirated piglets. | |
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MedLine Citation:
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PMID: 17654730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate if dynamic contrast-enhanced MRI in lungs could add new information to pulmonary hypertension in a newborn piglet model. MATERIALS AND METHODS: Six newborn piglets were subjected to instillation of meconium following treatment with sildenafil. Before and after both of these events, dynamic contrast-enhanced MRI was performed to determine pulmonary blood flow (PBF) using a model-free deconvolution of the dynamic signal-time curve, together with invasive measurements of mean airway pressure (PAW), cardiac output (CO), and oxygenation index (OI). RESULTS: Meconium instillation caused a significant increase in PAW (P < 0.05) accompanied by a marked increase in OI, the average PBF in the four lung regions (apical-anterior, apical-posterior, distal-anterior, and distal-posterior) decreased significantly by 33% (P < 0.001), but it did not significantly affect CO. On the other hand, infusion of sildenafil caused a significant increase in CO (P < 0.01), and administration resulted mainly in an increased PBF in the distal parts of the lungs. CONCLUSION: By using dynamic contrast-enhanced MRI, we demonstrated a marked decrease in PBF following instillation of meconium, which was not followed by an equivalent decrease in CO, suggesting that measurements of CO inadequately reflect the intrapulmonary changes in the blood circulation. |
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Authors:
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Pia Ryhammer; Michael Pedersen; Steffen Ringgaard; Hanne Ravn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 26 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-31 Completed Date: 2007-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 296-303 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Clinical Institute of Medicine, University of Aarhus, Aarhus, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Gas Analysis Body Temperature Contrast Media / pharmacology Humans Image Processing, Computer-Assisted Lung / pathology Magnetic Resonance Imaging / methods* Meconium / metabolism* Models, Biological Models, Theoretical Myocardium / metabolism Oxygen / metabolism Pulmonary Circulation Swine |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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