Document Detail


Regional neurohypophyseal blood flow and its control in adult sheep.
MedLine Citation:
PMID:  6787938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regional neurohypophyseal and cerebral blood flows were measured by the radiolabeled microsphere technique in 30 adult sheep under light barbiturate anesthesia. Regional blood flows were determined under basal conditions. The responses of regional blood flow to alterations in arterial PCO2 and to changes in arterial blood pressure wee also determined. In addition, the relationship between regional neurohypophyseal blood flow and neurosecretory activity as judged by plasma arginine vasopressin levels was assessed. Under basal conditions median eminence blood flow averaged 461 ml.100 g-1.min-1 and did not significantly differ from neural lobe blood flow (436 ml.100 g-1.min-1). Blood flow in the neurohypophysis was about 8 times cortical and 16 times white matter blood flow in these animals. Median eminence and neural lobe blood flow proportionately increased far less than regional cortical or white matter blood flow under conditions of hypercarbia. With alteration of arterial blood pressure, regional neurohypophyseal blood flow remained constant beyond the limits of cerebral autoregulation. The neurohypophysis demonstrates a degree of blood flow homeostasis that exceeds that of any other brain area studied. Although the neurohypophysis is a diverticulum of the brain, its vascular system forms a unique functional as well as a unique anatomic unit.
Authors:
R B Page; D J Funsch; R W Brennan; M J Hernandez
Related Documents :
2596338 - Acute effect of electroconvulsive therapy on brain perfusion assessed by tc99m-hexameth...
11377408 - Regional cerebral blood flow effects of nicotine in overnight abstinent smokers.
9918358 - Positron emission tomographic studies in restless legs syndrome.
1585798 - Regional cerebral blood flow after long-term exposure to carbon disulfide.
1888168 - Effect of unlabelled monoclonal antibodies on the biodistribution of 111in-labelled ant...
6798198 - Alterations of myocardial capillary permeability by albumin in the isolated, perfused r...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R36-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / blood
Blood Pressure
Brain / blood supply*
Carbon Dioxide / pharmacology
Female
Organ Specificity
Partial Pressure
Pituitary Gland, Posterior / blood supply*
Regional Blood Flow* / drug effects
Sheep
Grant Support
ID/Acronym/Agency:
NS-15926/NS/NINDS NIH HHS; NS00179/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Platelets, von Willebrand factor, and prostaglandin I2.
Next Document:  Survival from DIC following amniotic fluid embolism. Successful treatment with a serine proteinase i...