| Regional myocardial lidocaine concentration following continuous intravenous infusion early and later after myocardial infarction. | |
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MedLine Citation:
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PMID: 7113933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regional concentration of lidocaine using a double constant infusion technique (250 micrograms/kg/min x 15 minutes followed by 35 micrograms/kg/mg/min x 120 minutes) was studied immediately (2 hours) in seven dogs and 24 hours (six dogs) after myocardial infarction. Tissue levels were determined by gas chromatography and related to regional myocardial blood flow as determined by the radioactive microsphere technique in multiple samples. At 2 hours after infarction a significantly higher lidocaine concentration (4.1 +/- 0.42 micrograms/g) was found in zones with greatly reduced blood flow (regional myocardial blood flow less than 0.2 ml/min per g) when compared with that (2.6 +/- 0.19 micrograms/g) in zones with normal blood flow (regional myocardial blood flow greater than 0.8 ml/min per g) (p less than 0.01). In contrast, in the 24 hour model the opposite situation was observed. Although the concentration of lidocaine in the infarct zone was substantial, a significant decline in lidocaine tissue concentration was found in the zones of lowest blood flow (regional myocardial blood flow less than 0.2 ml/min per g) when compared with that in normal zones (1.76 +/- 0.21 versus 3.38 +/- 0.21 micrograms/g, p less than 0.001). In addition, no significant differences in lidocaine concentrations were found between endocardium and epicardium in any of the groups other than those related to regional myocardial blood flow. Thus, with the double constant infusion technique, lidocaine reached normal and ischemic myocardium in concentrations equivalent to therapeutic plasma concentrations, even in lower infarct blood flow zones, with no significant differences between endocardium and epicardium. Of perhaps greater significance, the age of the ischemic insult is an important determinant of lidocaine tissue distribution in infarcted myocardium. |
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Authors:
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R A Zito; V J Caride; T Holford; B L Zaret |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 50 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-10-12 Completed Date: 1982-10-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 497-502 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Gas Coronary Circulation Dogs Endocardium / analysis Female Infusions, Parenteral Lidocaine / administration & dosage, analysis, metabolism* Male Microspheres Myocardial Infarction / drug therapy*, metabolism Myocardium / analysis, metabolism* Pericardium / metabolism Radioactivity Time Factors Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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1-RO1-H122470//PHS HHS; R0-1-HL21690-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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