| Regional myocardial blood flow and ventricular arrhythmias following one-stage and two-stage coronary artery occlusion in anesthetized dogs. | |
| | |
MedLine Citation:
|
PMID: 7113893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experiments were performed in 29 anesthetized dogs to compare effects of one-stage and two-stage coronary artery occlusion on ventricular arrhythmias and regional myocardial blood flow (MBF). Two periods of arrhythmias were observed and both were associated with evidence suggesting reentry; i.e., activity in ischemic zone electrograms which bridged the diastolic intervals preceding ventricular ectopic beats. Early ventricular arrhythmias followed progressive deterioration of conduction in the ischemic zone, whereas later arrhythmias occurred unexpectedly with the sudden appearance of bridging activity. One-stage occlusion produced a higher incidence of ventricular arrhythmias and ventricular fibrillation than two-stage occlusion. However, there was no difference in central ischemic zone blood flow, indicating that the protective effect of two-stage occlusion was not due to greater blood flow in this region. There results suggest that factors other than the degree of MBF reduction are important determinants of the incidence and severity of ventricular arrhythmias following coronary artery occlusion. |
| | |
Authors:
|
G Kabell; B J Scherlag; R R Hope; R Lazzara |
Related Documents
:
|
22454363 - Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low de... 7372423 - External evaluation of regional cardiac lymph drainage in intact dogs. 2977543 - Long-term clinical and angiographic results following percutaneous transluminal coronar... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American heart journal Volume: 104 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1982 Sep |
Date Detail:
|
Created Date: 1982-10-12 Completed Date: 1982-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 537-44 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, General Animals Arrhythmias, Cardiac / etiology, physiopathology* Coronary Circulation* Coronary Vessels* Dogs Electrocardiography Heart Conduction System / physiopathology Myocardial Contraction Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
HL 23599/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanism of action of hyaluronidase in decreasing myocardial ischemia post coronary occlusion in th...
Next Document: Ventricular fibrillation complicating acute myocardial infarction: reasons against the routine use o...