| Regional morphology and biochemistry in experimental brain abscesses. | |
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MedLine Citation:
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PMID: 3962595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain abscesses were induced experimentally in six cats by stereotactic inoculation of Staphylococcus aureus A8 into the white matter of the left cerebral hemisphere. Seven days later, the brains were frozen in situ with liquid nitrogen and subsequently sawn into coronal sections of 5 mm thickness, while being cooled with liquid nitrogen. Thin slices were taken from those sections containing the largest expanse of abscess: slices of 5 micron thickness were stained histologically, and in adjacent 20 micron slices the regional distribution of ATP and glucose was mapped using substrate-specific bioluminescence methods. Furthermore, the NADH fluorescence from the surface of the tissue section was recorded. Six layers could be distinguished histologically in the abscess capsule, five of which showed different substrate patterns. Only in two layers a low metabolic activity could be observed, as shown by slight ATP bioluminescence. The pattern of the biochemical substrates in the white matter surrounding the abscess indicated a reduction in the cellular oxygen availability. |
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Authors:
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H W Bothe; W Paschen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neuropathologica Volume: 69 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-04-25 Completed Date: 1986-04-25 Revised Date: 2007-11-09 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Brain Abscess / metabolism, pathology* Cats Glucose / metabolism Luminescent Measurements Male NAD / metabolism Staphylococcal Infections / metabolism, pathology* Telencephalon / pathology* |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 53-84-9/NAD; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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