Document Detail


Regional mechanics determine collagen fiber structure in healing myocardial infarcts.
MedLine Citation:
PMID:  22418281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following myocardial infarction, the mechanical properties of the healing infarct are an important determinant of heart function and the risk of progression to heart failure. In particular, mechanical anisotropy (having different mechanical properties in different directions) in the healing infarct can preserve pump function of the heart. Based on reports of different collagen structures and mechanical properties in various animal models, we hypothesized that differences in infarct size, shape, and/or location produce different patterns of mechanical stretch that guide evolving collagen fiber structure. We tested the effects of infarct shape and location using a combined experimental and computational approach. We studied mechanics and collagen fiber structure in cryoinfarcts in 53 Sprague-Dawley rats and found that regardless of shape or orientation, cryoinfarcts near the equator of the left ventricle stretched primarily in the circumferential direction and developed circumferentially aligned collagen, while infarcts at the apex stretched similarly in the circumferential and longitudinal directions and developed randomly oriented collagen. In a computational model of infarct healing, an effect of mechanical stretch on fibroblast and collagen alignment was required to reproduce the experimental results. We conclude that mechanical environment determines collagen fiber structure in healing myocardial infarcts. Our results suggest that emerging post-infarction therapies that alter regional mechanics will also alter infarct collagen structure, offering both potential risks and novel therapeutic opportunities.
Authors:
Gregory M Fomovsky; Andrew D Rouillard; Jeffrey W Holmes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-07
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  52     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1083-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Computer Simulation
Fibrillar Collagens / chemistry,  metabolism*
Male
Mechanical Processes
Models, Biological
Myocardial Infarction / metabolism*,  pathology*
Myocardium / chemistry,  pathology*
Protein Structure, Quaternary
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
R01 HL-075639/HL/NHLBI NIH HHS; R01 HL075639/HL/NHLBI NIH HHS; R01 HL075639-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fibrillar Collagens
Comments/Corrections

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